The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
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The role of lysine 532 in the catalytic mechanism of human topoisomerase ITargeted disruption of the mouse topoisomerase I gene by camptothecin selectionBiochemical and biophysical analyses of recombinant forms of human topoisomerase IThe role of histidine 632 in catalysis by human topoisomerase I.Molecular characterization of recombinant Pneumocystis carinii topoisomerase I: differential interactions with human topoisomerase I poisons and pentamidine.Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.TOPOISOMERASE1α Acts through Two Distinct Mechanisms to Regulate Stele and Columella Stem Cell Maintenance.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivityInteraction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sitesA novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitorsHuman Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell linesIn vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.Processing of topoisomerase I cleavable complexes into DNA damage by transcription.Transcription-dependent degradation of topoisomerase I-DNA covalent complexesInduction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin.DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the proteinBenzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.Topoisomerase I is preferentially associated with normal SV40 replicative intermediates, but is associated with both replicating and nonreplicating SV40 DNAs which are deficient in histones.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Paranemic structures of DNA and their role in DNA unwinding.Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plantsSingle-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence.Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase ISequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study.Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.Cellular strategies for regulating DNA supercoiling: a single-molecule perspectiveA functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay.Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.Modeling of DNA local parameters predicts encrypted architectural motifs in Xenopus laevis ribosomal gene promoter.Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa.Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1.Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors.Preferential binding of human topoisomerase I to superhelical DNA.Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.Topoisomerase I action on the heterochromatic DNA from the brine shrimp Artemia franciscana: studies in vivo and in vitro.DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin.DNA topological context affects access to eukaryotic DNA topoisomerase I.
P2860
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P2860
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@ast
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@en
type
label
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@ast
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@en
prefLabel
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@ast
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@en
P2860
P356
P1476
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.
@en
P2093
Champoux JJ
P2860
P304
P356
10.1093/NAR/17.21.8521
P407
P577
1989-11-01T00:00:00Z