Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.
about
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effectsSubstrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatinThe interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p538-Oxoguanine rearranges the active site of human topoisomerase IStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexDNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.Proteomic approach to identification of proteins reactive for abasic sites in DNA.Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesteraseSensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesionsPolymer-based dense fluidic networks for high throughput screening with ultrasensitive fluorescence detection.Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromesTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).A method for detecting abasic sites in living cells: age-dependent changes in base excision repairBase excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro.Human mitochondrial topoisomerase IConversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing.Human topoisomerase I cleavage complexes are repaired by a p53-stimulated recombination-like reaction in vitro.Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.Role for topoisomerase 1 in transcription-associated mutagenesis in yeastNeurological disorders associated with DNA strand-break processing enzymes.Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell linesRecognition and repair of chemically heterogeneous structures at DNA endsBenzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.A type IB topoisomerase with DNA repair activitiesSynthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.Repair of topoisomerase I-mediated DNA damage.The involvement of DNA-damage and -repair defects in neurological dysfunctionTyrosyl-DNA phosphodiesterase as a target for anticancer therapyThe modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adeninePosition- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures.
P2860
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P2860
Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Effects of uracil incorporatio ...... of mammalian topoisomerase I.
@en
type
label
Effects of uracil incorporatio ...... of mammalian topoisomerase I.
@en
prefLabel
Effects of uracil incorporatio ...... of mammalian topoisomerase I.
@en
P2093
P2860
P356
P1476
Effects of uracil incorporatio ...... of mammalian topoisomerase I.
@en
P2093
Kohlhagen G
Mazumder A
Pourquier P
P2860
P304
P356
10.1074/JBC.272.12.7792
P407
P577
1997-03-01T00:00:00Z