Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.
about
The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseasesSelf-propagation of pathogenic protein aggregates in neurodegenerative diseasesPassive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy modelsSpreading of pathology in neurodegenerative diseases: a focus on human studiesThe preclinical phase of the pathological process underlying sporadic Alzheimer's diseaseDistinct α-synuclein strains differentially promote tau inclusions in neuronsProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusNovel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins.Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Using Human iPSC-Derived Neurons to Model TAU Aggregation.Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connectionsIdentification of disulfide cross-linked tau dimer responsible for tau propagationTargeting protein aggregation for the treatment of degenerative diseasesCalcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neuronsDistinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease.Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β.Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathiesUnique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins.Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases.Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies.Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.Protein aggregates stimulate macropinocytosis facilitating their propagationMonoaminergic neuropathology in Alzheimer's disease.Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks.Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction.Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.Are tau aggregates toxic or protective in tauopathies?Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein.Emerging Diagnostic and Therapeutic Strategies for Tauopathies.Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain.GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.The use of mouse models to study cell-to-cell transmission of pathological tau.CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.
P2860
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P2860
Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Neurofibrillary tangle-like ta ...... ns over-expressing mutant tau.
@en
type
label
Neurofibrillary tangle-like ta ...... ns over-expressing mutant tau.
@en
prefLabel
Neurofibrillary tangle-like ta ...... ns over-expressing mutant tau.
@en
P2860
P1433
P1476
Neurofibrillary tangle-like ta ...... ns over-expressing mutant tau.
@en
P2093
Jing L Guo
Virginia M Y Lee
P2860
P304
P356
10.1016/J.FEBSLET.2013.01.051
P407
P577
2013-02-05T00:00:00Z