Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. - Wikidata - wikimedia - TriplyDB

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

http://www.wikidata.org/entity/Q36299911

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Matrix crosslinking forces tumor progression by enhancing integrin signaling NEDD9 promotes oncogenic signaling in mammary tumor development.β1 and β4 integrins: from breast development to clinical practice Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers FAK in cancer: mechanistic findings and clinical applications Apc mutation enhances PyMT-induced mammary tumorigenesis A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression Integrins in cancer: biological implications and therapeutic opportunities Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1 The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.CrkII transgene induces atypical mammary gland development and tumorigenesis.Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.CXCR1/2 pathways in paclitaxel-induced neuropathic pain Dormancy of metastatic melanoma Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells.Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis Mammary gland growth factors: roles in normal development and in cancer.Quantification of epithelial cell differentiation in mammary glands and carcinomas from DMBA- and MNU-exposed rats.beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.Oncogenes and tumor suppressor genes Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs.Hypoxia and the extracellular matrix: drivers of tumour metastasis Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells A tumor-suppressing function in the epithelial adhesion protein Trask.

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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

http://www.wikidata.org/entity/Q36299911

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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Mammary epithelial-specific di ...... cks mammary tumor progression.

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Mammary epithelial-specific di ...... cks mammary tumor progression.

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type

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Mammary epithelial-specific di ...... cks mammary tumor progression.

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Mammary epithelial-specific di ...... cks mammary tumor progression.

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Mammary epithelial-specific di ...... cks mammary tumor progression.

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PNAS.0710091104

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Proceedings of the National Academy of Sciences of the United States of America

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Mammary epithelial-specific di ...... cks mammary tumor progression.

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Dongmei Zuo

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Gordon W McLean

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Hicham Lahlou

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Robert D Cardiff

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Virginie Sanguin-Gendreau

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William J Muller

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P2860

Integrin-regulated FAK-Src signaling in normal and cancer cells

Generalized lacZ expression with the ROSA26 Cre reporter strain

FAK regulates biological processes important for the pathogenesis of cancer

Focal adhesion kinase: in command and control of cell motility

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

Cellular characterization of a novel focal adhesion kinase inhibitor.

Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli

Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.

Control of motile and invasive cell phenotypes by focal adhesion kinase.

Integrin signalling during tumour progression.

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20302-20307

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104

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Margaret C Frame

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5790843

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2154426

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