Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.
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Matrix crosslinking forces tumor progression by enhancing integrin signalingNEDD9 promotes oncogenic signaling in mammary tumor development.β1 and β4 integrins: from breast development to clinical practiceWhy the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkersFAK in cancer: mechanistic findings and clinical applicationsApc mutation enhances PyMT-induced mammary tumorigenesisA requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 miceBi-directional signaling: extracellular matrix and integrin regulation of breast tumor progressionIntegrins in cancer: biological implications and therapeutic opportunitiesDifferential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate modelCoronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.CrkII transgene induces atypical mammary gland development and tumorigenesis.Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.CXCR1/2 pathways in paclitaxel-induced neuropathic painDormancy of metastatic melanomaMammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells.Integrin signaling through FAK in the regulation of mammary stem cells and breast cancerFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisMammary gland growth factors: roles in normal development and in cancer.Quantification of epithelial cell differentiation in mammary glands and carcinomas from DMBA- and MNU-exposed rats.beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progressionOral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.Oncogenes and tumor suppressor genesMammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progressionDeletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs.Hypoxia and the extracellular matrix: drivers of tumour metastasisCompensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkageUnderstanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsCollagen density regulates xenobiotic and hypoxic response of mammary epithelial cellsA tumor-suppressing function in the epithelial adhesion protein Trask.
P2860
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P2860
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Mammary epithelial-specific di ...... cks mammary tumor progression.
@ast
Mammary epithelial-specific di ...... cks mammary tumor progression.
@en
type
label
Mammary epithelial-specific di ...... cks mammary tumor progression.
@ast
Mammary epithelial-specific di ...... cks mammary tumor progression.
@en
prefLabel
Mammary epithelial-specific di ...... cks mammary tumor progression.
@ast
Mammary epithelial-specific di ...... cks mammary tumor progression.
@en
P2093
P2860
P356
P1476
Mammary epithelial-specific di ...... cks mammary tumor progression.
@en
P2093
Dongmei Zuo
Gordon W McLean
Hicham Lahlou
Robert D Cardiff
Virginie Sanguin-Gendreau
William J Muller
P2860
P304
20302-20307
P356
10.1073/PNAS.0710091104
P407
P577
2007-12-03T00:00:00Z