Light chain replacement: a new model for antibody gene rearrangement
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Frequent N addition and clonal relatedness among immunoglobulin lambda light chains expressed in rheumatoid arthritis synovia and PBL, and the influence of V lambda gene segment utilization on CDR3 lengthLong-Range Regulation of V(D)J RecombinationB cell receptor editing in tolerance and autoimmunityPhylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebratesAnalysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood systemic lupus erythematosusTwo distinct populations of H chain-edited B cells show differential surrogate L chain dependence.PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cellsCD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.Receptor selection in B and T lymphocytes.The role of rearrangement at the second Ig heavy chain locus in maintaining B cell tolerance to DNA.CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.A stepwise epigenetic process controls immunoglobulin allelic exclusion.Immunoglobulin variable-region gene usage in systemic autoimmune diseases.Receptor editing in lymphocyte development and central tolerance.Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia.Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.Receptor revision and systemic lupus.Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.Alternative mechanisms of receptor editing in autoreactive B cells.Systematic analysis of sequences of anti-DNA antibodies--relevance to theories of origin and pathogenicity.B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.Kappa chain monoallelic demethylation and the establishment of allelic exclusion.Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escapeB-cell antigen-receptor signalling in lymphocyte development.Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilitiesThe catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombinationThe BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation.Persistent expression of autoantibodies in SLE patients in remission.Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells.DNA-dependent protein kinase activity is not required for immunoglobulin class switching.Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomasHuman autoantibody silencing by immunoglobulin light chainsTolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded.Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism.Regulation of anti-DNA B cells in recombination-activating gene-deficient mice.
P2860
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P2860
Light chain replacement: a new model for antibody gene rearrangement
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Light chain replacement: a new model for antibody gene rearrangement
@ast
Light chain replacement: a new model for antibody gene rearrangement
@en
type
label
Light chain replacement: a new model for antibody gene rearrangement
@ast
Light chain replacement: a new model for antibody gene rearrangement
@en
prefLabel
Light chain replacement: a new model for antibody gene rearrangement
@ast
Light chain replacement: a new model for antibody gene rearrangement
@en
P2860
P356
P1476
Light chain replacement: a new model for antibody gene rearrangement
@en
P2093
P2860
P304
P356
10.1084/JEM.182.2.541
P407
P577
1995-08-01T00:00:00Z