A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease
about
The central and multiple roles of B cells in lupus pathogenesis.PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cellsCD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse modelDysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupusNucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.From T to B and back again: positive feedback in systemic autoimmune disease.Free radical theory of autoimmunitySystematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilitiesSurrogate light chain expressing human peripheral B cells produce self-reactive antibodies.Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupusToll-like receptors and their role in the development of autoimmune diseases.Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cellsRegulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides.Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell helpVery low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reducedPositive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell developmentThe cellular location of self-antigen determines the positive and negative selection of autoreactive B cellsAutoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice.Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.Maintenance of the plasma cell pool is independent of memory B cells.Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivityTLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses.Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptorsAdoptive Transfer of Memory B Cells.The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivoA new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formationB cells and immunological tolerance.Regulation of autoreactive B cell responses to endogenous TLR ligands.Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.Immunodrugs: breaking B- but not T-cell tolerance with therapeutic anticytokine vaccines.The role of B lymphocyte stimulator in B cell biology: implications for the treatment of lupus.Memory B cells in mouse models.Contributions of B cells to lupus pathogenesisDendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand.
P2860
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P2860
A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@ast
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@en
type
label
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@ast
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@en
prefLabel
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@ast
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@en
P2093
P2860
P356
P1476
A disease-related rheumatoid f ...... tibodies in autoimmune disease
@en
P2093
A M Haberman
L G Hannum
M G Weigert
M J Shlomchik
P2860
P304
P356
10.1084/JEM.184.4.1269
P407
P577
1996-10-01T00:00:00Z