Repair of topoisomerase I-mediated DNA damage. - Wikidata - wikimedia - TriplyDB

Repair of topoisomerase I-mediated DNA damage.

Repair of topoisomerase I-mediated DNA damage.

http://www.wikidata.org/entity/Q36557533

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Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK Targeting DNA topoisomerase II in cancer chemotherapy Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy Drugging topoisomerases: lessons and challenges A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors.Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Role of oxidatively induced DNA lesions in human pathogenesis Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses Stress activated protein kinase pathway modulates homologous recombination in fission yeast Role for topoisomerase 1 in transcription-associated mutagenesis in yeast Genome maintenance in Saccharomyces cerevisiae: the role of SUMO and SUMO-targeted ubiquitin ligases.Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.Mycoplasma fermentans inhibits the activity of cellular DNA topoisomerase I by activation of PARP1 and alters the efficacy of its anti-cancer inhibitor Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction.DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.Quantitative characterization of protein-protein complexes involved in base excision DNA repair Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.

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Repair of topoisomerase I-mediated DNA damage.

http://www.wikidata.org/entity/Q36557533

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Repair of topoisomerase I-mediated DNA damage.

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Repair of topoisomerase I-mediated DNA damage.

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Repair of topoisomerase I-mediated DNA damage.

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Repair of topoisomerase I-mediated DNA damage.

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Repair of topoisomerase I-mediated DNA damage.

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Progress in Molecular Biology and Translational Science

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Repair of topoisomerase I-mediated DNA damage.

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Andrew G Jobson

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Christophe Marchand

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Christophe Redon

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Hongliang Zhang

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Jennifer A Seiler

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John L Nitiss

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Juana M Barcelo

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Keli Agama

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Laurent Thibaut

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Olivier Sordet

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P2860

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

Molecular characterization of a human DNA kinase

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Cellular roles of dna topoisomerases: a molecular perspective

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

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