Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta.
about
DNA polymerase family X: function, structure, and cellular rolesReplication infidelity via a mismatch with Watson–Crick geometryBidentate and tridentate metal-ion coordination states within ternary complexes of RB69 DNA polymeraseβ,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA PolymerasesAmino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer ReactionUnfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayStructural Basis for Promutagenicity of 8-Halogenated GuanineMetal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase βTransition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanineStructures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity MechanismClustered DNA lesions containing 5-formyluracil and AP site: repair via the BER systemPolymerase-tailored variations in the water-mediated and substrate-assisted mechanism for nucleotidyl transfer: insights from a study of T7 DNA polymerase.Revealing the role of the product metal in DNA polymerase β catalysis.The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase βLee Pedersen's work in theoretical and computational chemistry and biochemistryPrechemistry versus preorganization in DNA replication fidelity.Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.An abridged transition state model to derive structure, dynamics, and energy components of DNA polymerase β fidelity.Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.Perspective: pre-chemistry conformational changes in DNA polymerase mechanismsComputational simulation strategies for analysis of multisubunit RNA polymerases.Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.Why nature really chose phosphate.Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization.Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.Metal Fluorides: Tools for Structural and Computational Analysis of Phosphoryl Transfer Enzymes.Computational delineation of the catalytic step of a high-fidelity DNA polymerase.A computational study of the hydrolysis of dGTP analogues with halomethylene-modified leaving groups in solution: implications for the mechanism of DNA polymerases.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase βSubstrate recognition by norovirus polymerase: microsecond molecular dynamics study.Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase β.Prechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting
P2860
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P2860
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta.
description
2008 nî lūn-bûn
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2008年の論文
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2008年論文
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2008年論文
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2008年論文
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2008年論文
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2008年論文
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2008年论文
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2008年论文
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name
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@ast
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@en
type
label
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@ast
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@en
prefLabel
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@ast
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@en
P2093
P2860
P356
P1476
Incorrect nucleotide insertion ...... alyzed by DNA polymerase beta.
@en
P2093
Lars C Pedersen
Lee G Pedersen
Samuel H Wilson
Vinod K Batra
William A Beard
P2860
P304
P356
10.1073/PNAS.0801257105
P407
P577
2008-04-07T00:00:00Z