about
Computational design of a PDZ domain peptide inhibitor that rescues CFTR activityDesign of a Novel Globular Protein Fold with Atomic-Level AccuracyParadigms for computational nucleic acid designNative protein sequences are close to optimal for their structuresPrinciples and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsSolution structure and dynamics of a de novo designed three-helix bundle proteinRotamer strain as a determinant of protein structural specificityRetrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteinsConversion of monomeric protein L to an obligate dimer by computational protein designCysteine-free rop: A four-helix bundle core mutant has wild-type stability and structure but dramatically different unfolding kineticsProtein design: Past, present, and futureDesign, synthesis, and characterization of a novel hemoproteinA graph-theory algorithm for rapid protein side-chain predictionFolding specificity induced by loop stiffnessStructural and kinetic characterization of the simplified SH3 domain FP1.Effects of Non-Natural Amino Acid Incorporation into the Enzyme Core Region on Enzyme Structure and Function.Tanford-Kirkwood electrostatics for protein modeling.Protein topology and stability define the space of allowed sequences.Rotamer optimization for protein design through MAP estimation and problem-size reduction.The Framework of Computational Protein Design.Achievements and Challenges in Computational Protein Design.Dead-end elimination with perturbations (DEEPer): a provable protein design algorithm with continuous sidechain and backbone flexibility.Protein design automation.De novo design of the hydrophobic core of ubiquitin.A method to rationally increase protein stability based on the charge-charge interaction, with application to lipase LipK107.Histidine placement in de novo-designed heme proteins.Folding free energy function selects native-like protein sequences in the core but not on the surface.Stabilizing the subtilisin BPN' pro-domain by phage display selection: how restrictive is the amino acid code for maximum protein stability?A test of the relationship between sequence and structure in proteins: excision of the heme binding site in apocytochrome b5.Improved side-chain prediction accuracy using an ab initio potential energy function and a very large rotamer libraryStatistical theory for protein ensembles with designed energy landscapes.IPRO: an iterative computational protein library redesign and optimization procedureEmergence of protein fold families through rational designA search for energy minimized sequences of proteinsCombinatorial design of protein sequences with applications to lattice and real proteins.Computational design of antibody-affinity improvement beyond in vivo maturationDe novo backbone scaffolds for protein design.Computational design of membrane proteins.Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases.Protein design is NP-hard.
P2860
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P2860
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
De novo design of the hydrophobic cores of proteins.
@en
type
label
De novo design of the hydrophobic cores of proteins.
@en
prefLabel
De novo design of the hydrophobic cores of proteins.
@en
P2860
P356
P1433
P1476
De novo design of the hydrophobic cores of proteins.
@en
P2093
Desjarlais JR
P2860
P304
P356
10.1002/PRO.5560041006
P577
1995-10-01T00:00:00Z