Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
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Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationGlycyrrhetinic acid might increase the nephrotoxicity of bakuchiol by inhibiting cytochrome P450 isoenzymesScreening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometerStable-isotope dilution LC–MS for quantitative biomarker analysis.The role of metabolites in predicting drug-drug interactions: focus on irreversible cytochrome P450 inhibition.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Application of LC-high-resolution MS with 'intelligent' data mining tools for screening reactive drug metabolites.Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen.ADME of biologics-what have we learned from small molecules?Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway.Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.Covalent protein binding and tissue distribution of houttuynin in rats after intravenous administration of sodium houttuyfonate.The biological significance of methionine sulfoxide stereochemistry.Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis.NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST.Managing the challenge of chemically reactive metabolites in drug development.Drug metabolite profiling and identification by high-resolution mass spectrometry.A review of the use of in silico methods to predict the chemistry of molecular initiating events related to drug toxicity.Preclinical in vivo ADME studies in drug development: a critical review.The generation, detection, and effects of reactive drug metabolites.Selecting oral bioavailability enhancing formulations during drug discovery and development.Hepatic metabolism: a key component of herbal drugs research.Applying machine learning techniques for ADME-Tox prediction: a review.Detecting reactive drug metabolites for reducing the potential for drug toxicity.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.Quantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies.Preparative microfluidic electrosynthesis of drug metabolites.Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.In Vitro Drug Metabolism Using Liver Microsomes.Pro-apoptotic effects of Kangfuxin on human stomach cancer cells and its underlying mechanism.Cytochromes P450 as useful biocatalysts: addressing the limitations
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Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 December 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@en
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@nl
type
label
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@en
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@nl
prefLabel
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@en
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@nl
P356
P1476
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
@en
P2093
Thomas A Baillie
P304
P356
10.1021/TX7002273
P577
2007-12-04T00:00:00Z