Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development
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Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 proteinAdaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbationsTranslational control by heme-regulated eIF2α kinase during erythropoiesisBioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected miceUIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver StagesEndoplasmic reticulum stress in periimplantation embryosEukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatmentTranslation of 5' leaders is pervasive in genes resistant to eIF2 repressionHomozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disabilityPlacental Origins of Chronic Disease.A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.Protective unfolded protein response in human pancreatic beta cells transplanted into mice.Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and developmentA point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.Regulation of the unfolded protein response by eif2Bdelta isoforms.Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosisPreventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunitThe extended PP1 toolkit: designed to create specificity.Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes.Getting the better of ER stress.Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.DNA Damage Regulates Translation through β-TRCP Targeting of CRePThe unpredictability of prolonged activation of stress response pathways.A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translationStructural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein SynthesiseIF2α Confers Cellular Tolerance to S. aureus α-Toxin.KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in miceRibosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation.A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and MicrocephalyAn inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ppp1r15 gene knockout reveals ...... ation in mammalian development
@en
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha
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type
label
Ppp1r15 gene knockout reveals ...... ation in mammalian development
@en
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha
@nl
prefLabel
Ppp1r15 gene knockout reveals ...... ation in mammalian development
@en
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha
@nl
P2093
P2860
P356
P1476
Ppp1r15 gene knockout reveals ...... ation in mammalian development
@en
P2093
Donalyn Scheuner
Jane-Jane Chen
Randal J Kaufman
Yuhong Zhang
P2860
P304
P356
10.1073/PNAS.0809632106
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P577
2009-01-30T00:00:00Z