Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.
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Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapyMolecular programming of B cell memoryStructural Insight into Translesion Synthesis by DNA Pol IIAID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Loss of DNA polymerase zeta enhances spontaneous tumorigenesis.Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζREV3L, a promising target in regulating the chemosensitivity of cervical cancer cells.The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.DNA polymerase ζ generates tandem mutations in immunoglobulin variable regionsDNA polymerase zeta is required for proliferation of normal mammalian cells.Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ.Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats.Assessment of copy number variations in 120 patients with Poland syndrome.REV7 counteracts DNA double-strand break resection and affects PARP inhibitionDual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.DNA polymerases and cancer.DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genesDNA damage tolerance and a web of connections with DNA repair at Yale.Polk mutant mice have a spontaneous mutator phenotype.A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions.Breakthrough for a DNA break-preventer.AID: a riddle wrapped in a mystery inside an enigma.Translesion DNA synthesis in the context of cancer research.Mouse models of DNA polymerases.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.Translesion DNA synthesis and mutagenesis in eukaryotesInhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.AID Biology: A pathological and clinical perspective.Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination
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Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 09 February 2009
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Pol zeta ablation in B cells i ...... repair, and genome stability.
@en
Pol zeta ablation in B cells i ...... repair, and genome stability.
@nl
type
label
Pol zeta ablation in B cells i ...... repair, and genome stability.
@en
Pol zeta ablation in B cells i ...... repair, and genome stability.
@nl
prefLabel
Pol zeta ablation in B cells i ...... repair, and genome stability.
@en
Pol zeta ablation in B cells i ...... repair, and genome stability.
@nl
P2093
P2860
P356
P1476
Pol zeta ablation in B cells i ...... repair, and genome stability.
@en
P2093
Dominik Schenten
Frederick W Alt
Gloria Esposito
Michael Murphy
Sonia Franco
Sven Kracker
P2860
P304
P356
10.1084/JEM.20080669
P407
P577
2009-02-09T00:00:00Z