Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
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Promiscuous DNA synthesis by human DNA polymerase θDNA polymerase θ (POLQ), double-strand break repair, and cancerDNA Polymerase θ: A Unique Multifunctional End-Joining MachineMechanism of suppression of chromosomal instability by DNA polymerase POLQAnalysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activityLesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.Human DNA polymerase θ grasps the primer terminus to mediate DNA repairThe Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.Linking DNA polymerase theta structure and function in health and diseaseDNA polymerase POLQ and cellular defense against DNA damage.DNA polymerases and cancer.Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival.A role for DNA polymerase θ in the timing of DNA replication.Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells.A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.Expression and Structural Analyses of Human DNA Polymerase θ (POLQ).Characterization of DNA repair deficient strains of Chlamydomonas reinhardtii generated by insertional mutagenesis.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ.
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P2860
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Lack of DNA polymerase theta ( ...... after total-body irradiation.
@en
Lack of DNA polymerase theta
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type
label
Lack of DNA polymerase theta ( ...... after total-body irradiation.
@en
Lack of DNA polymerase theta
@nl
prefLabel
Lack of DNA polymerase theta ( ...... after total-body irradiation.
@en
Lack of DNA polymerase theta
@nl
P2093
P2860
P356
P1433
P1476
Lack of DNA polymerase theta ( ...... after total-body irradiation.
@en
P2093
Christopher J Bakkenist
Donna S Shields
Dorothea K Torous
Joel S Greenberger
John Wittschieben
Julie P Goff
Mineaki Seki
Serah Choi
Stephen D Dertinger
P2860
P304
P356
10.1667/RR1598.1
P577
2009-08-01T00:00:00Z