Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.
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Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalizationHLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cellsDefective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expressionA role for calnexin (IP90) in the assembly of class II MHC moleculesInvariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1Interaction of human immunodeficiency virus type 2 Vpx and invariant chain.Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41.Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity.Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation.Influenza vaccine responses in older adults.Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsRelationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes.The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancyInvariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells.Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexesDistinct binding sites on HLA-DR for invariant chain and staphylococcal enterotoxins.Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome.Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response.Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.Influenza vaccination in the elderly: seeking new correlates of protection and improved vaccines.Fusion to the Lysosome Targeting Signal of the Invariant Chain Alters the Processing and Enhances the Immunogenicity of HIV-1 Reverse TranscriptaseImmunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults.Trimeric interactions of the invariant chain and its association with major histocompatibility complex class II alpha beta dimers.Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.Invariant Chain Complexes and Clusters as Platforms for MIF Signaling.Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.Endocytic recycling is required for the presentation of an exogenous peptide via MHC class II molecules.Cellular and molecular aspects of antigen processing and the function of class II MHC molecules.Cellular distribution of a mixed MHC class II heterodimer between DRalpha and a chimeric DObeta chain.The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts.Association of the invariant chain with major histocompatibility complex class I molecules directs trafficking to endocytic compartments.Epitope-specific enhancement of antigen presentation by invariant chain.Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells.Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.
P2860
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P2860
Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Invariant chain targets HLA cl ...... internalized influenza virus.
@en
Invariant chain targets HLA cl ...... internalized influenza virus.
@nl
type
label
Invariant chain targets HLA cl ...... internalized influenza virus.
@en
Invariant chain targets HLA cl ...... internalized influenza virus.
@nl
prefLabel
Invariant chain targets HLA cl ...... internalized influenza virus.
@en
Invariant chain targets HLA cl ...... internalized influenza virus.
@nl
P2093
P2860
P356
P1476
Invariant chain targets HLA cl ...... internalized influenza virus.
@en
P2093
J R Bennink
J W Yewdell
P Cresswell
P2860
P304
P356
10.1073/PNAS.88.14.5998
P407
P577
1991-07-01T00:00:00Z