Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
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Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycNHuman proto-oncogene N-myc encodes nuclear proteins that bind DNAMechanisms of multistep carcinogenesis and carcinogen risk assessmentRetroviral oncogenes: a historical primerIncreased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene productAlternative processing of RNA transcribed from NMYCNucleotide sequence of the 3' exon of the human N-myc geneNucleotide sequence of the human N-myc geneStructure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processingSparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cellsTopology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines.Identification of tumor-related proteins by proteomic analysis of cerebrospinal fluid from patients with primary brain tumors.Regulation of MYCN expression in human neuroblastoma cells.Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication.Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence.Herpes simplex virus oncolytic therapy for pediatric malignanciesDNA analysis in human diseaseN-myc gene product expression in neuroblastoma.Nucleotide sequence of the coding region of the mouse N-myc gene2p24 Gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma: biological and clinical characteristics.MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma.Role of Id family proteins in growth control.Chromogranin A expression in normal and malignant human tissuesCellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessmentRole of proto-oncogene activation in carcinogenesis.Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.Dominant and recessive molecular changes in neuroblastomas.Human small-cell lung cancers show amplification and expression of the N-myc gene.The cancer treatment revolutionMYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model.A study of myc-related gene expression in small cell lung cancer by in situ hybridization.Detection of N-myc gene expression in neuroblastoma tumors by in situ hybridization.Histogenesis and clonality of pancreatic tumors induced by v-myc and v-raf oncogenes in NFS/N mice.Temporal order of gene replication in Chinese hamster ovary cells.Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.Neoplastic transformation by the human gene N-mycTargeting ALK in neuroblastoma--preclinical and clinical advancements.microRNA profiling identifies cancer-specific and prognostic signatures in pediatric malignancies.Identification and characterization of the NMYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities.
P2860
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P2860
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1984
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Enhanced expression of the hum ...... progression of neuroblastoma.
@en
Enhanced expression of the hum ...... progression of neuroblastoma.
@nl
type
label
Enhanced expression of the hum ...... progression of neuroblastoma.
@en
Enhanced expression of the hum ...... progression of neuroblastoma.
@nl
prefLabel
Enhanced expression of the hum ...... progression of neuroblastoma.
@en
Enhanced expression of the hum ...... progression of neuroblastoma.
@nl
P2093
P2860
P356
P1476
Enhanced expression of the hum ...... progression of neuroblastoma.
@en
P2093
P2860
P304
P356
10.1073/PNAS.81.15.4940
P407
P577
1984-08-01T00:00:00Z