Proteasomal dysfunction in aging and Huntington disease.
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Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorderCRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative DiseasesIron dysregulation in Huntington's diseaseAgeing and Parkinson's disease: why is advancing age the biggest risk factor?Huntington's disease: underlying molecular mechanisms and emerging conceptsSynaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing.When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?BAG3 is involved in neuronal differentiation and migration.Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation.Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpinsImmunoproteomic analysis of potential serum biomarker candidates in human glaucoma.Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.Coordinated processing of 3' slipped (CAG)n/(CTG)n hairpins by DNA polymerases β and δ preferentially induces repeat expansions.Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.Membrane trafficking in neuronal maintenance and degeneration.The role of autophagy dysregulation in manganese-induced dopaminergic neurodegenerationRhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy.Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells.Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteinsProtein homeostasis, aging and Alzheimer's disease.The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models.Cellular stress responses in protein misfolding diseasesHuntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain.Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism.Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo.It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin.Evidence for the Deregulation of Protein Turnover Pathways in Atm-Deficient Mouse Cerebellum: An Organotypic Study.Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans.RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.
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Proteasomal dysfunction in aging and Huntington disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 December 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Proteasomal dysfunction in aging and Huntington disease.
@en
Proteasomal dysfunction in aging and Huntington disease.
@nl
type
label
Proteasomal dysfunction in aging and Huntington disease.
@en
Proteasomal dysfunction in aging and Huntington disease.
@nl
prefLabel
Proteasomal dysfunction in aging and Huntington disease.
@en
Proteasomal dysfunction in aging and Huntington disease.
@nl
P2860
P1476
Proteasomal dysfunction in aging and Huntington disease.
@en
P2093
Xiao-Jiang Li
P2860
P356
10.1016/J.NBD.2010.11.018
P577
2010-12-08T00:00:00Z