Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.
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Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatmentN-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptorIdentification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site."Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsDiscovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencySynthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.Pd-Catalyzed C-H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones.
P2860
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P2860
Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Discovery of N-Aryl Piperazines as Selective mGlu
@nl
Discovery of N-Aryl Piperazine ...... ve of Anti-Psychotic Activity.
@en
type
label
Discovery of N-Aryl Piperazines as Selective mGlu
@nl
Discovery of N-Aryl Piperazine ...... ve of Anti-Psychotic Activity.
@en
prefLabel
Discovery of N-Aryl Piperazines as Selective mGlu
@nl
Discovery of N-Aryl Piperazine ...... ve of Anti-Psychotic Activity.
@en
P2093
P2860
P356
P1476
Discovery of N-Aryl Piperazine ...... ve of Anti-Psychotic Activity.
@en
P2093
Alice L Rodriguez
C David Weaver
Carrie K Jones
Elizabeth J Hermann
Emily L Days
Jason T Manka
Paige N Vinson
Satyawan Jadhav
Shaun R Stauffer
P2860
P304
P356
10.1021/ML100181A
P577
2010-08-13T00:00:00Z