p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
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Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Regulation of the 26S proteasome by adenovirus E1AAdenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-regionDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexAnalysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexInactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.Suppression of E1A-mediated transformation by the p50E4F transcription factorDNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cellsE1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S.Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis.Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.The adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription.Suppression of adenovirus E1A-induced apoptosis by mutated p53 is overcome by coexpression with Id proteins.The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 statusE1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosisAdenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes.Bak and Bax function to limit adenovirus replication through apoptosis induction.Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing.
P2860
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P2860
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
@en
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
@nl
type
label
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
@en
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
@nl
prefLabel
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
@en
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.
@nl
P2860
P1433
P1476
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis
@en
P2093
P2860
P304
P407
P577
1997-05-01T00:00:00Z