Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes - Wikidata - wikimedia - TriplyDB

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

http://www.wikidata.org/entity/Q39922812

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Melanoma: from melanocyte to genetic alterations and clinical options The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer Cellular and Molecular Responses to Mechanical Expansion of Tissue A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2 Trihydrophobin 1 is a new negative regulator of A-Raf kinase B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation Upregulation and maintenance of gap junctional communication in lens cells cAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells.p38 regulates pigmentation via proteasomal degradation of tyrosinase.Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms.Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).High frequency of BRAF mutations in nevi.Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit Validation of the VE1 immunostain for the BRAF V600E mutation in melanoma.Skin phototype: a new perspective.Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Melanocortin MC₁ receptor in human genetics and model systems.Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR.Carney complex and lentiginosis Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.Ultraviolet radiation and cutaneous malignant melanoma.Search for new cyclic AMP-binding proteins.Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs.

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Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

http://www.wikidata.org/entity/Q39922812

description

2000 nî lūn-bûn

@nan

2000年の論文

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2000年学术文章

@wuu

2000年学术文章

@zh-cn

2000年学术文章

@zh-hans

2000年学术文章

@zh-my

2000年学术文章

@zh-sg

2000年學術文章

@yue

2000年學術文章

@zh

2000年學術文章

@zh-hant

name

Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes

@en

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases

@nl

type

label

Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes

@en

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases

@nl

prefLabel

Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes

@en

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases

@nl

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The EMBO Journal

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Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes

@en

P2093

C Peyssonnaux

http://www.w3.org/2001/XMLSchema#string

E Aberdam

http://www.w3.org/2001/XMLSchema#string

F Mantoux

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J P Ortonne

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P Abbe

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R Buscà

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

Phosphorylation and regulation of Raf by Akt (protein kinase B)

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system

Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation

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2900-2910

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scholarly article

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10.1093/EMBOJ/19.12.2900

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12

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19

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Robert Ballotti

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2000-06-01T00:00:00Z

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12462895

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10856235

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203360

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