PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
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MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasionRho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarityA novel regulatory mechanism links PLCγ1 to PDK1Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damageThe Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbingRho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapyROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.Cell motility through plasma membrane blebbingRho, ROCK and actomyosin contractility in metastasis as drug targetsNovel Insights into the Roles of Rho Kinase in CancerThe Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular DiseaseAt the leading edge of three-dimensional cell migrationRegulation of ROCK activity in cancerTumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkersRho GTPases in collective cell migrationMatrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signalingAn improved chamber for direct visualisation of chemotaxisA Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell InvasionReduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cellsTumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITORZF21 Protein, a Regulator of the Disassembly of Focal Adhesions and Cancer Metastasis, Contains a Novel Noncanonical Pleckstrin Homology DomainPathophysiological Functions of Rnd3/RhoEFormin-like 2 drives amoeboid invasive cell motility downstream of RhoCRnd3 as a Novel Target to Ameliorate Microvascular LeakageRhoA regulates peroxisome association to microtubules and the actin cytoskeletonModulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxiaPhosphoinositide 3-kinase p85beta regulates invadopodium formation.Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensionsA chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement.FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migrationPDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.ROCK1 and LIMK2 interact in spread but not blebbing cancer cellsRhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.ROCK1 as a potential therapeutic target in osteosarcoma.Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts.
P2860
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P2860
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
@en
type
label
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
@en
prefLabel
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
@en
P2860
P356
P1433
P1476
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
@en
P2093
Sophie Pinner
P2860
P2888
P304
P356
10.1038/NCB1675
P50
P577
2008-01-20T00:00:00Z