Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
about
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesG2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone CompoundIn Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I MetabolitesIron chelators in photodynamic therapy revisited: synergistic effect by novel highly active thiosemicarbazones.DNA binding, prominent DNA cleavage and efficient anticancer activities of tris(diimine)iron(II) complexes.Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.Advances in iron chelation: an update.A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells.Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats.Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers.Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types.Thiosemicarbazones: the new wave in cancer treatment.Iron chelation in the treatment of cancer: a new role for deferasirox?Cytotoxic activity of expanded coordination bis-thiosemicarbazones and copper complexes thereof.Investigation of the cytotoxic implications of metal chelators against melanoma and approaches to improve the cytotoxicity profiles of metal coordinating agents.Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro.Increased generation of intracellular reactive oxygen species initiates selective cytotoxicity against the MCF-7 cell line resultant from redox active combination therapy using copper-thiosemicarbazone complexes.Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores.Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(I/II) complexes of thiosemicarbazone: special emphasis on their interactions with DNA.Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity.Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity.Interaction with DNA and different effect on the nucleus of cancer cells for copper(II) complexes of N-benzyl di(pyridylmethyl)amine.The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.A novel mTOR inhibitor is efficacious in a murine model of colitis.Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells.Iron Chelators and Exogenic Photosensitizers. Synergy through Oxidative Stress Gene Expression.Synthesis and Antimycobacterial Activity of Symmetric Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG.Effects of oral iron chelator deferasirox on human malignant lymphoma cells.Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation.LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia.Synthesis of Dipyridyl Ketone Isonicotinoyl Hydrazone Copper(II) Complex: Structure, Anticancer Activity and Anticancer Mechanism.Coordination versatility of tridentate pyridyl aroylhydrazones towards iron: tracking down the elusive aroylhydrazono-based ferric spin-crossover molecular materials.
P2860
Q28388335-EF3EC8A9-07D7-4A3C-97A6-1295FE9B13BAQ28547905-A4339C53-761D-4D76-8792-B9B9EF16BD9CQ28550205-C4D9EC62-6229-4870-8B6F-4466989812E3Q33636546-BEAFD50A-B026-4E9B-AEFE-E1DE90A241D5Q33835903-2620D74D-23FB-4BE4-9D10-F94A7BDD6AA2Q33864513-CAB3364F-EEBA-48CE-91AB-51103BAE3831Q34174307-7E840B4B-B6C0-432A-8178-E9BC48D18C50Q34208541-707488A0-829B-4DDB-8E77-82808A73C9B4Q34458484-C25A68CC-2972-461B-B373-75B0B2050719Q34869589-B8F637E5-E62B-4298-8E0B-77FE7EC7D300Q35047321-CF2614E3-2A3D-4244-9FC8-B368CFE9B95EQ35348485-5686AE78-5E62-449A-ADCF-B70A878E9BBAQ35351758-257D7644-931B-4190-8EF5-FA0E67C8E810Q35657936-374BDC9C-51EF-4AAC-9117-38FF0EDD2BC3Q35833012-E8A3172B-5A4B-4994-B56F-243913FA2413Q36278270-233BF4C4-B836-4504-B140-871976E99717Q36557412-B2CF6103-0000-4524-BBF6-0871FF12EF7BQ37855829-73D1E420-F6AD-4F76-8B13-C1926C26068DQ38112400-4D29CC87-58EA-4A7D-8375-BD59754D060CQ38744982-81319691-BC30-4C39-A4C0-2A261B68171FQ38759275-8673ADB3-6FAE-452B-8965-9329A4C254BBQ38769040-D9DCBC99-D53F-4A04-96E7-DE89F6D2A3D2Q38788219-9900A3AF-DD8A-4A2D-9C90-FF619EA7C107Q38810643-476FA67D-D5EB-4E66-8808-D9BCA5337434Q38904045-A414CE50-041B-4914-A314-FC19A68F6084Q39107491-8C127D4F-1A87-4D29-9278-0381A8588BF6Q39391002-23B95301-BFD4-4984-9DD4-94958AD81C1CQ39576895-A01F10B3-A353-4943-95E6-D867BD5A332CQ39870984-6902AE08-7CE4-416C-B7A9-E86523A23761Q39928484-4016FA96-B541-4372-B965-360E23640386Q40812626-677274CD-5B0C-4FBD-951F-344235932736Q41439828-A4C789EB-B308-4BA6-A9DB-F2A3B7463192Q41970367-5F26BC64-15D5-441E-AAAC-C32157F9EEA1Q42233318-D531F703-4E33-4F35-8AB2-4A2638551D2AQ43176490-83108486-1FE4-4FE5-9955-6A869ACE69CBQ44883757-880B80E6-53F6-40C2-BC72-F674CE1F79C0Q45228449-45C0ED04-00E8-4753-A5A8-0DB881AFD57AQ46044542-CAD3B031-3D16-4A01-9D51-52771F4DFF46Q46468084-F15AA166-BB92-4A67-895D-A3550B808000Q50666742-5E3EDDD7-5C16-4FE9-AECE-365A9FB7BFC8
P2860
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Design, synthesis, and charact ...... es as potent antitumor agents.
@en
type
label
Design, synthesis, and charact ...... es as potent antitumor agents.
@en
prefLabel
Design, synthesis, and charact ...... es as potent antitumor agents.
@en
P50
P356
P1476
Design, synthesis, and charact ...... ues as potent antitumor agents
@en
P2093
Mohammad Islam
Yi-Tyng Liao
P304
P356
10.1021/JM070445Z
P407
P577
2007-06-30T00:00:00Z