The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells.
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Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cellsStructural basis for complement factor H linked age-related macular degenerationThe complotype: dictating risk for inflammation and infectionGenetic variants in the complement system predisposing to age-related macular degeneration: a reviewRPE necroptosis in response to oxidative stress and in AMDThe stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocityPentraxins: structure, function, and role in inflammationTranslational mini-review series on complement factor H: genetics and disease associations of human complement factor H.Complement factor H: using atomic resolution structure to illuminate disease mechanisms.Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.Complement therapy in atypical haemolytic uraemic syndrome (aHUS).Self-nonself discrimination by the complement system.Identification of novel substrates for the serine protease HTRA1 in the human RPE secretomeComplement control protein factor H: the good, the bad, and the inadequate.Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Identification of acidic pH-dependent ligands of pentameric C-reactive protein.Lack of complement inhibitors in the outer intracranial artery aneurysm wall associates with complement terminal pathway activation.The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical applicationThe C-type lectin of the aggrecan G3 domain activates complement.Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injuryAprioriGWAS, a new pattern mining strategy for detecting genetic variants associated with disease through interaction effects.C-reactive protein protects mice against pneumococcal infection via both phosphocholine-dependent and phosphocholine-independent mechanisms.A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in miceExposing a hidden functional site of C-reactive protein by site-directed mutagenesisAge-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus.The connection between C-reactive protein and atherosclerosisPlasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.Complement Dysregulation and Disease: Insights from Contemporary Genetics.Complement dysregulation in AMD: RPE-Bruch's membrane-choroidThe phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infectionComplement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variantsIncreased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration.The role of the immune response in age-related macular degenerationDominant suppression of inflammation by glycan-hydrolyzed IgGTranslational mini-review series on complement factor H: structural and functional correlations for factor H.Complement activation by bisretinoid constituents of RPE lipofuscinThe protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection.
P2860
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P2860
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The factor H variant associate ...... ulin, DNA, and necrotic cells.
@en
type
label
The factor H variant associate ...... ulin, DNA, and necrotic cells.
@en
prefLabel
The factor H variant associate ...... ulin, DNA, and necrotic cells.
@en
P2093
P2860
P50
P356
P1476
The factor H variant associate ...... ulin, DNA, and necrotic cells.
@en
P2093
Andreas P Sjöberg
Dick Heinegård
Jonatan Sjölander
P2860
P304
10894-10900
P356
10.1074/JBC.M610256200
P407
P577
2007-02-09T00:00:00Z