Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
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Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaThe TOR pathway comes of ageJudicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesmTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTORStimulation of autophagy improves endoplasmic reticulum stress-induced diabetesSilencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretionWhy men age faster but reproduce longer than women: mTOR and evolutionary perspectivesMIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cellsThe UPS in diabetes and obesity.Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1.Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation.Glucose infusion in mice: a new model to induce beta-cell replication.Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets.A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin BDecreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cellsThe cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.mTORC1 signaling and regulation of pancreatic β-cell mass.Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury.Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 AxisPosttransplant metabolic syndrome.On the role of IRS2 in the regulation of functional beta-cell mass.Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.Answering the ultimate question "what is the proximal cause of aging?"Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in miceConstitutively active Rheb induces oncogenic transformation.Direct autocrine action of insulin on β-cells: does it make physiological sense?Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growthDegradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.Expression and function of the insulin receptor substrate proteins in cancerRapamycin inhibits growth factor-induced cell cycle regulation in pancreatic beta cellsInvolvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.PRAS40: target or modulator of mTORC1 signalling and insulin action?Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor
P2860
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P2860
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Insulin receptor substrate-2 p ...... gnaling pathway in beta-cells.
@en
type
label
Insulin receptor substrate-2 p ...... gnaling pathway in beta-cells.
@en
prefLabel
Insulin receptor substrate-2 p ...... gnaling pathway in beta-cells.
@en
P2093
P2860
P356
P1476
Insulin receptor substrate-2 p ...... gnaling pathway in beta-cells.
@en
P2093
Christopher J Rhodes
Isabelle Briaud
Jill F McCuaig
John C Lawrence
Lorna M Dickson
Melissa K Lingohr
P2860
P304
P356
10.1074/JBC.M412179200
P407
P577
2004-11-09T00:00:00Z