Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
about
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activityRoles of Werner syndrome protein in protection of genome integrityHuman premature aging, DNA repair and RecQ helicasesClose encounters for the first time: Helicase interactions with DNA damageThe Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradationCharacterization of the helicase activity and substrate specificity of Mycobacterium tuberculosis UvrDA helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A.ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicaseMechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.Molecular analyses of DNA helicases involved in the replicational stress response.Small molecule inhibitors of DNA repair nuclease activities of APE1.Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonucleaseHuman RecQ helicases in DNA repair, recombination, and replication.Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry.The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling.Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structuresEnhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome proteinMechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityFANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stabilityMechanistic insight into cadmium-induced inactivation of the Bloom protein.CDK1 phosphorylates WRN at collapsed replication forks.RecQ helicases: multiple structures for multiple functions?Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding.RecQ helicases; at the crossroad of genome replication, repair, and recombination.Multiple Escherichia coli RecQ helicase monomers cooperate to unwind long DNA substrates: a fluorescence cross-correlation spectroscopy study.Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain.Regulation of the human Suv3 helicase on DNA by inorganic cofactors.The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
P2860
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P2860
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Biochemical and kinetic charac ...... es of werner syndrome protein.
@en
type
label
Biochemical and kinetic charac ...... es of werner syndrome protein.
@en
prefLabel
Biochemical and kinetic charac ...... es of werner syndrome protein.
@en
P2093
P2860
P356
P1476
Biochemical and kinetic charac ...... es of werner syndrome protein.
@en
P2093
Joshua A Sommers
Robert M Brosh
Saba Choudhary
P2860
P304
34603-34613
P356
10.1074/JBC.M401901200
P407
P577
2004-06-08T00:00:00Z