Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.
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Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathwayOligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitationDefining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersTransporter oligomerization: form and functionOligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix IIRole of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein couplingTwo discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1)Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome.GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETGABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsTurnover rate of the gamma-aminobutyric acid transporter GAT1.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.Transmembrane peptide as potent inhibitor of oligomerization and function of human organic anion transporter 1.Microseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuTThe serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting.Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane.Direct PIP2 binding mediates stable oligomer formation of the serotonin transporterThe reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango.The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum.The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs.Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.Cognate Ligand Chaperoning: a Novel Mechanism for the Post-translational Regulation of Neurotransmitter Receptor Biogenesis.A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1)Glycine transporter dimers: evidence for occurrence in the plasma membrane.Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24CInteraction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1.Oligomeric structure of the neutral amino acid transporters KAAT1 and CAATCH1.A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization.Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor.Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs.Roles of transmembrane domain 2 and the first intracellular loop in human noradrenaline transporter function: pharmacological and SCAM analysis.Effect of hyperosmotic conditions on the expression of the betaine-GABA-transporter (BGT-1) in cultured mouse astrocytes.Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.
P2860
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P2860
Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Mutations within an intramembr ...... of the rat GABA transporter 1.
@en
type
label
Mutations within an intramembr ...... of the rat GABA transporter 1.
@en
prefLabel
Mutations within an intramembr ...... of the rat GABA transporter 1.
@en
P2860
P356
P1476
Mutations within an intramembr ...... of the rat GABA transporter 1.
@en
P2093
Michael Freissmuth
Petra Scholze
P2860
P304
43682-43690
P356
10.1074/JBC.M205602200
P407
P577
2002-09-09T00:00:00Z