Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage.
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Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection PathwaysInhibition of IGF-1 signalling enhances the apoptotic effect of AS602868, an IKK2 inhibitor, in multiple myeloma cell lines.Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachMiR-223 suppresses cell proliferation by targeting IGF-1R.The proliferating role of insulin and insulin-like growth factors in cancer.MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R.Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy.Prostate cancer: another aspect of the insulin-resistance syndrome?Analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention.Therapeutic destruction of insulin receptor substrates for cancer treatment.Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth.A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loopRole of insulin-like growth factor 1 receptor signalling in cancer.Effects of creatine monohydrate supplementation on exercise-induced apoptosis in athletes: A randomized, double-blind, and placebo-controlled studyRegulation of MDMX expression by mitogenic signaling.Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes.p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells.Obesity as a major risk factor for cancer.Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.IGF-IR in neuroprotection and brain tumors.Ursolic Acid-Regulated Energy Metabolism-Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage?Monoclonal antibodies: potential new therapeutic treatment against multiple myeloma.Low-fidelity compensatory backup alternative DNA repair pathways may unify current carcinogenesis theories.Cardioprotection by the transfer of coronary effluent from ischaemic preconditioned rat hearts: identification of cardioprotective humoral factors.BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell lineOnly Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.SiRNA-mediated IGF-1R inhibition sensitizes human colon cancer SW480 cells to radiation.Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer--evaluation of the prognostic significance of these agents.Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastomaRole of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response.Neuroendocrine prostate cancer (NEPCa) increased the neighboring PCa chemoresistance via altering the PTHrP/p38/Hsp27/androgen receptor (AR)/p21 signals.Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells.P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation.Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro.Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions.
P2860
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P2860
Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Insulin-like growth factor I i ...... way in response to DNA damage.
@en
type
label
Insulin-like growth factor I i ...... way in response to DNA damage.
@en
prefLabel
Insulin-like growth factor I i ...... way in response to DNA damage.
@en
P2860
P356
P1476
Insulin-like growth factor I i ...... way in response to DNA damage.
@en
P2093
Lisa Héron-Milhavet
P2860
P304
15600-15606
P356
10.1074/JBC.M111142200
P407
P577
2002-02-27T00:00:00Z