Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy: distinct behavior of granule motion in biphasic insulin release.
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Distinct initial SNARE configurations underlying the diversity of exocytosisDistinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cellsGranuphilin exclusively mediates functional granule docking to the plasma membrane.Applications of phototransformable fluorescent proteins for tracking the dynamics of cellular componentsPreferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosisInsulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool releaseDistinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluoresceImaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis.Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.Visualization of regulated exocytosis with a granule-membrane probe using total internal reflection microscopy.Water secretion associated with exocytosis in endocrine cells revealed by micro forcemetry and evanescent wave microscopy.Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting granules for release.Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM.Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cellsThree-dimensional tracking of single secretory granules in live PC12 cellsFluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosisCell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Motion matters: secretory granule motion adjacent to the plasma membrane and exocytosisEssential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy.Proinsulin maturation, misfolding, and proteotoxicity.Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoformsStatistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cellsGranuphilin molecularly docks insulin granules to the fusion machinery.Glucose-sensing mechanisms in pancreatic beta-cells.How neurosecretory vesicles release their cargo.A 20-nm step toward the cell membrane preceding exocytosis may correspond to docking of tethered granules.Insulin exocytotic mechanism by imaging technique.A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance.Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.Imaging beta-cell mass and function in situ and in vivo.Granule mobility, fusion frequency and insulin secretion are differentially affected by insulinotropic stimuli.
P2860
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P2860
Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy: distinct behavior of granule motion in biphasic insulin release.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Imaging exocytosis of single i ...... n in biphasic insulin release.
@en
type
label
Imaging exocytosis of single i ...... n in biphasic insulin release.
@en
prefLabel
Imaging exocytosis of single i ...... n in biphasic insulin release.
@en
P2093
P2860
P356
P1476
Imaging exocytosis of single i ...... n in biphasic insulin release.
@en
P2093
Hitoshi Ishida
Mica Ohara-Imaizumi
Shinya Nagamatsu
Toshiaki Tanaka
Yoko Nakamichi
P2860
P304
P356
10.1074/JBC.C100712200
P407
P577
2001-12-21T00:00:00Z