Normal and abnormal biology of the beta-amyloid precursor protein.
about
Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brainFibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological functionAmyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signalingPresenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauFe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor proteinBinding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NACP3 beta-amyloid peptide has a unique and potentially pathogenic immunohistochemical profile in Alzheimer's disease brainSolution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domainMint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's diseaseFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinThe intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid systemAbeta amyloid fibrils possess a core structure highly resistant to hydrogen exchangeAmyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent mannerAge-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive declineComparison of the structures of beta amyloid peptide (25-35) and substance P in trifluoroethanol/water solution.Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation.An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease.Neurotoxicity of advanced glycation end-products for cultured cortical neurons.Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscleTesting the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognitionAmyloid and lipids in the pathology of Alzheimer disease.My Mind Project: the effects of cognitive training for elderly-the study protocol of a prospective randomized intervention study.Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formationCellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.Circulating biomarkers that predict incident dementia.Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis.Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic micePhysicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.Amyloid-fibril formation. Proposed mechanisms and relevance to conformational disease.Solubilization of beta-amyloid-(1-42)-peptide: reversing the beta-sheet conformation induced by aluminum with silicates.A brief overview of amyloids and Alzheimer's disease.Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.Plasma Aβ and PET PiB binding are inversely related in mild cognitive impairment.
P2860
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P2860
Normal and abnormal biology of the beta-amyloid precursor protein.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Normal and abnormal biology of the beta-amyloid precursor protein.
@en
type
label
Normal and abnormal biology of the beta-amyloid precursor protein.
@en
prefLabel
Normal and abnormal biology of the beta-amyloid precursor protein.
@en
P1476
Normal and abnormal biology of the beta-amyloid precursor protein.
@en
P2093
P304
P356
10.1146/ANNUREV.NE.17.030194.002421
P577
1994-01-01T00:00:00Z