Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells.
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Polycystin-1: a master regulator of intersecting cystic pathwaysIdentification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complexPolycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion.Polycystin-1 interacts with intermediate filaments.Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.Receptor protein tyrosine phosphatases are novel components of a polycystin complexNovel targets for the treatment of autosomal dominant polycystic kidney disease.Polycystin-1 activates and stabilizes the polycystin-2 channel.Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney diseasePolycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis.Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1Structure-function relationships of the extracellular domain of the autosomal dominant polycystic kidney disease-associated protein, polycystin-1.Altered trafficking and stability of polycystins underlie polycystic kidney disease.Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney diseaseTight junction biology and kidney dysfunction.Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS sitePolycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1.Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategiesTight junction composition is altered in the epithelium of polycystic kidneys.Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potentialEmerging evidence of a link between the polycystins and the mTOR pathways.Polycystins, focal adhesions and extracellular matrix interactionsPolycystins and cellular Ca2+ signaling.Cell polarity and cystic kidney disease.Strategies targeting cAMP signaling in the treatment of polycystic kidney disease.Polycystins and partners: proposed role in mechanosensitivity.The primary cilium calcium channels and their role in flow sensing.Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease.On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.Polycystin and calcium signaling in cell death and survival.Shear stress reverses dome formation in confluent renal tubular cells.Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cellsThe ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation.More than colocalizing with polycystin-1, polycystin-L is in the centrosome.Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease.The Roles of Primary cilia in Polycystic Kidney Disease.
P2860
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P2860
Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Polycystin-1, the product of t ...... with desmosomes in MDCK cells.
@en
type
label
Polycystin-1, the product of t ...... with desmosomes in MDCK cells.
@en
prefLabel
Polycystin-1, the product of t ...... with desmosomes in MDCK cells.
@en
P2093
P356
P1476
Polycystin-1, the product of t ...... with desmosomes in MDCK cells.
@en
P2093
Breuning MH
Litvinov SV
Scheffers MS
van der Bent P
P304
P356
10.1093/HMG/9.18.2743
P577
2000-11-01T00:00:00Z