Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.C-terminal phosphorylation controls the stability and function of p27kip114-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrestCRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisNovel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functionsTransforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor proteinTargeting Cancer Metabolism - Revisiting the Warburg EffectsExtra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disordersRegulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysisPCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.p27Kip1 localization depends on the tumor suppressor protein tuberin.EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy.Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells.The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiationParadigms of growth control: relation to Cdk activation.A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppressionHunk is required for HER2/neu-induced mammary tumorigenesis.p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomasAkt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical regionBlockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.Regulation of CDK4Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.Screening of cell cycle fusion proteins to identify kinase signaling networksMyc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.Protein Mobility Shifts Contribute to Gel Electrophoresis Liquid Chromatography Analysis.Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cellsA crosstalk imbalance between p27(Kip1) and its interacting molecules enhances breast carcinogenesisIL-7 promotes T cell proliferation through destabilization of p27Kip1.The priming/completion paradigm to explain growth factor-dependent cell cycle progression.The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines.Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulationPin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process.AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD.
P2860
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P2860
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
Phosphorylation at serine 10, ...... creases its protein stability.
@en
type
label
Phosphorylation at serine 10, ...... creases its protein stability.
@en
prefLabel
Phosphorylation at serine 10, ...... creases its protein stability.
@en
P2093
P356
P1476
Phosphorylation at serine 10, ...... creases its protein stability.
@en
P2093
P304
25146-25154
P356
10.1074/JBC.M001144200
P407
P577
2000-08-01T00:00:00Z