Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.
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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseHuman amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluidFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinMice lacking both presenilin genes exhibit early embryonic patterning defectsPeptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's diseaseEndogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Biology of presenilins as causative molecules for Alzheimer disease.Function and dysfunction of the presenilinsThe seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells.The role of presenilins in Alzheimer's disease.Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.Regulation of APP cleavage by alpha-, beta- and gamma-secretases.Apoptosis modulators in the therapy of neurodegenerative diseases.The Role of presenilins in gamma-secretase activity.Familial conformational diseases and dementias.The functions of the amyloid precursor protein gene.The message and the messenger: delivering RNA in neurons.The JNK/c-Jun cascade and Alzheimer's disease.Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis.Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathyGenetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Presenilin function and gamma-secretase activity.Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.Cell surface expression of the Alzheimer disease-related presenilin proteins.Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease.Pharmacological enhancement of neuronal survival.Molecular genetics of Alzheimer's disease: an update.Twenty Years of Presenilins--Important Proteins in Health and Disease.Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.The role of amyloid in the pathogenesis of Alzheimer's disease.Alzheimer's disease and brain development: common molecular pathways.Apoptosis, neurotrophic factors and neurodegeneration.Responses of Cultured Astrocytes, C6 Glioma and 1321NI Astrocytoma Cells to Amyloid beta-Peptide Fragments.Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neuronsRole of the ErbB-4 carboxyl terminus in gamma-secretase cleavage.Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1.
P2860
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P2860
Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Formation of stable complexes ...... eta-amyloid precursor protein.
@en
type
label
Formation of stable complexes ...... eta-amyloid precursor protein.
@en
prefLabel
Formation of stable complexes ...... eta-amyloid precursor protein.
@en
P2093
P2860
P356
P1433
P1476
Formation of stable complexes ...... eta-amyloid precursor protein.
@en
P2093
Beyreuther K
Dürrwang U
Masters CL
Weidemann A
P2860
P2888
P304
P356
10.1038/NM0397-328
P407
P577
1997-03-01T00:00:00Z
P6179
1045664611