Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism.
about
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseRegulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cellsFyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsDAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinaseTULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.Altered thymic positive selection and intracellular signals in Cbl-deficient miceAdapter molecules in T cell receptor signaling.Cbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein tip.Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling.SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts.Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway.Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl.The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling.CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor.The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
P2860
Q22008672-84826DA9-BAD5-44B6-B3CF-FDE401AB7B15Q28140642-903E31F7-0BEF-4E88-A872-A4F2D4F941BCQ28609046-FFDC0C82-4993-4E88-A3C5-BF2C22C48EBDQ28610866-4414D3E1-CC1A-4944-958C-25D566F7E1FBQ30164133-BE8ACC2F-7910-4958-8647-7E9F889F6837Q30167736-91986E57-B155-41EC-BA6C-6BFCFEE20474Q30175249-400418AF-6010-49AC-87D6-C74846B63BB0Q31672728-DEE75517-A569-41F1-A46E-E53B4E8B52A4Q33596728-C39A619E-CC70-42D6-86EC-C0120BFD94BAQ33641570-03F5A088-4D59-4E76-899D-17BC0D3656E8Q34205572-E236D61A-089F-4519-90D1-F285EA44E0A9Q34405560-B81B1D9D-AA35-4431-A5BA-9C49DBAB44DAQ37710951-0BB28025-F4DA-47C5-8765-E98A0BB9BFDAQ40889559-3100FD4B-FAF4-4BFD-AE70-97B550CC39F3Q40908376-528BDD0A-70CC-4D69-A954-4C7233F51119Q40919280-A4199F1E-9FD1-48DF-AEFE-F2A8231DA90DQ40944647-C7DC4730-92F7-4A98-9682-8CAB35C45A7CQ41655291-5D87C5A9-C5EA-4AA1-9D61-16A7D2D15C8BQ42485920-B2011CAD-B6C7-4CA8-A928-C32CB74B819AQ42831849-9FC3327F-FDE8-472E-ABFD-820F004E55A3Q43483568-EACB0C93-306A-4AE4-9C1D-32107ECF474AQ44605241-33DC7820-32CB-410A-B30C-7A5C720CF14AQ45989111-46711259-5E69-40B2-B753-E6871400F9FF
P2860
Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Formation of c-Cbl.phosphatidy ...... p56lck-independent mechanism.
@en
type
label
Formation of c-Cbl.phosphatidy ...... p56lck-independent mechanism.
@en
prefLabel
Formation of c-Cbl.phosphatidy ...... p56lck-independent mechanism.
@en
P2860
P356
P1476
Formation of c-Cbl.phosphatidy ...... p56lck-independent mechanism.
@en
P2093
P2860
P304
21939-21943
P356
10.1074/JBC.271.36.21939
P407
P577
1996-09-01T00:00:00Z