p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.
about
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseClass II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptorsIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblA novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytesNegative regulation of PI 3-kinase by Ruk, a novel adaptor proteinGrb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factorcbl-b inhibits epidermal growth factor receptor signalingInterleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsCoordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinasesThe CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cellsEpidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytesCharacterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cellsPhosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinaseControlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimersInteractions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysAmphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibitionCbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFRc-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment.Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Signal transduction pathways that contribute to myeloid differentiation.Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells.Expression of activated type I receptor tyrosine kinases in early breast cancer.Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway.Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling.Signaling pathways leading to transcription and translation cooperatively regulate the transient increase in expression of c-Fos protein.Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.c-Cbl is a suppressor of the neu oncogene.Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase.Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signalingAssociation between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophagesFormation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism.Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes.Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.
P2860
Q22008672-66650706-8873-4090-9CAB-A788029C5E60Q22254063-1A4125AD-2D74-4FE5-90AB-28D6326CF8CAQ24313251-774A6C15-D40E-4CCE-8225-5A5B3EBD5FC6Q24324468-64BB947F-7ACE-4D29-A9ED-9B8BD3198664Q24630479-A3297279-5279-4B7F-B35D-2F33E9E15872Q24648537-C8A6CAA6-42F9-466F-900F-068AF8FE0F8BQ28139234-5FAE15DD-D13F-4FCE-AEC9-D7D47AD525E6Q28261435-92D6C0DF-07A3-491F-AC0D-8764FD0513EAQ28267092-B8A4E2E6-A858-485D-A949-66B9661CF594Q28272735-694B3291-47BB-4541-9F26-C3F825E83505Q28571849-2DFB108F-EA02-4AE5-9609-7D692727E6FBQ28575312-F861ABA0-F26E-432E-86D6-DFA535024323Q28609041-764990F2-3FE8-442E-828F-D07FA06ABC43Q28679173-1D8F635D-A759-4C01-AFA2-63B4CC704410Q30176591-E34E3312-5221-4AA5-B000-02CF8FDDE01EQ30176934-A53DEAAF-9DE5-4C55-9756-6D254DCF9191Q31672728-ADBDB826-22DF-4A96-99D2-B748D011453EQ31924344-E5254444-820F-4FF4-BDAB-B0EA16FC495CQ33737298-CCBEC92D-FF1C-43D6-9D2F-85D1CA1B8E23Q33880093-57F35228-E120-4BCF-844F-212484112495Q33948376-E1902FF2-77BE-4CF4-98CD-D9F7CA92D375Q34075493-F7FD3C2E-5BD0-42CD-A0E8-ABCB3E340C67Q34250032-43617656-6C88-42C8-AAAC-A7F1C1771213Q34688703-DCB65999-BB04-49A5-B05D-FB4831DD4CCFQ35635353-1D02F7B2-1C06-42DD-B6C4-31E7A1319CF6Q36795284-FEA5EB51-1EE7-4474-A1C0-E40CA54F64F8Q38328408-86403B4B-D039-41B7-8BE5-4AACE63F8F7AQ38458901-DFCFA848-B7FA-499E-83AF-DDE3E00B99F6Q40624347-D5341085-5B03-4A49-83B8-79F9C3FF7344Q40663248-B021D71C-AC69-4411-90F3-6198E5322689Q40806188-2162777E-6E6B-4D2B-85DA-2E0D7F6B203DQ40849405-6306D332-B8D3-4740-91D0-14FA61480039Q40862177-F039EC78-4CA9-4D9D-920B-B42666188D1DQ40884544-ED39C2AA-4424-422D-8EA7-B0314E3FD2F4Q40933654-0CE982B8-A61F-42A5-A000-9B2492E8103FQ41150880-7878C8DF-CEB7-4454-8037-F3985DB833E2Q41168715-946DBBFF-A2A4-4B32-9405-35B73C5F18D4Q41861046-73A9C5B1-EF66-4E99-88B3-1A5197D68951Q42467870-1808F830-BB4A-479F-9EA9-A9E6D79EE32FQ42528757-1E67B155-AE34-4C36-9143-09C1847EA0EF
P2860
p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@ast
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@en
type
label
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@ast
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@en
prefLabel
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@ast
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@en
P2860
P356
P1476
p120cbl is a cytosolic adapter ...... actor in PC12 and other cells.
@en
P2093
L C Cantley
S P Soltoff
P2860
P304
P356
10.1074/JBC.271.1.563
P407
P577
1996-01-01T00:00:00Z