Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
about
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor familySoluble interleukin-6 receptor triggers osteoclast formation by interleukin 6Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3Structure of the extracellular domains of the human interleukin-6 receptor alpha -chainInflammation and Alzheimer's diseaseDistinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells.Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cellsRole of the C-terminus in the activity, conformation, and stability of interleukin-6.Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding.Interleukin-6: structure-function relationships.Epistasis analysis links immune cascades and cerebral amyloidosis.Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulationExpression of the interleukin 6 receptor in primary renal cell carcinoma.Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.Role of leucine residues in the C-terminal region of human interleukin-6 in the biological activity.Site-specific mutagenesis of human interleukin-6 and its biological activity.The interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex.IL-17F co-expression improves cell growth characteristics and enhances recombinant protein production during CHO cell line engineering.Intercellular adhesion molecule-1 on synovial cells attenuated interleukin-6-induced inhibition of osteoclastogenesis induced by receptor activator for nuclear factor κB ligand.Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritisSoluble receptors for cytokines and growth factors: generation and biological function.Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor.Serum levels of IL-6 and its soluble receptor (sIL-6R) in Waldenström's macroglobulinemia.Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cellsGp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways.Soluble interleukin-6 receptor is released from receptor-bearing cell lines in vitro.A multiscale model of interleukin-6-mediated immune regulation in Crohn's disease and its application in drug discovery and development.Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells.Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells.Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor.The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex.Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
P2860
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P2860
Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
@en
type
label
Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
@en
prefLabel
Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
@en
P2093
P1476
Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
@en
P2093
Fukunaga T
Koishihara Y
Sekimori Y
Yasukawa K
P304
P356
10.1093/OXFORDJOURNALS.JBCHEM.A123261
P577
1990-10-01T00:00:00Z