Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes.
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Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domainsSilencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeletonSignal-dependent membrane targeting by pleckstrin homology (PH) domainsOverexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activityThe phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradationCeramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocationOxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytesThe inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activityKinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from living mice.Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transferFocal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cellsActivation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate.ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes.Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.Lighting up insulin action.Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes.Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cellsReporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems.Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriersDetection and manipulation of phosphoinositides.Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing.Phosphoinositide and inositol phosphate analysis in lymphocyte activationImaging phosphoinositide dynamics using GFP-tagged protein domains."Actin"g on GLUT4: membrane & cytoskeletal components of insulin action.Visualizing and quantifying adhesive signals.In vivo imaging of GLUT4 translocation.Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC.Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencingInsulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation eventDisruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes.Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts.Differential protein phosphorylation in 3T3-L1 adipocytes in response to insulin versus platelet-derived growth factor. No evidence for a phosphatidylinositide 3-kinase-independent pathway in insulin signaling.Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells.
P2860
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P2860
Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Confocal imaging of the subcel ...... -stimulated 3T3-L1 adipocytes.
@en
type
label
Confocal imaging of the subcel ...... -stimulated 3T3-L1 adipocytes.
@en
prefLabel
Confocal imaging of the subcel ...... -stimulated 3T3-L1 adipocytes.
@en
P2093
P2860
P1433
P1476
Confocal imaging of the subcel ...... -stimulated 3T3-L1 adipocytes.
@en
P2093
A G Williams
E J Foulstone
J M Tavaré
K Venkateswarlu
L M Fletcher
P J Cullen
P2860
P304
P356
10.1042/0264-6021:3440511
P407
P478
P577
1999-12-01T00:00:00Z