GAT1 (GABA:Na+:Cl-) cotransport function. Database reconstruction with an alternating access model.
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Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modesA trimeric quaternary structure is conserved in bacterial and human glutamate transportersCommon mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransportersMutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactionsRole of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent.Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1Rapid substrate-induced charge movements of the GABA transporter GAT1.Substrate-dependent proton antiport in neurotransmitter:sodium symporters.Sucrose- and H-dependent charge movements associated with the gating of sucrose transporter ZmSUT1Comparison of human solute carriersIonic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesisTurnover rate of the gamma-aminobutyric acid transporter GAT1.Novel properties of a mouse gamma-aminobutyric acid transporter (GAT4).From a pump to a pore: how palytoxin opens the gates.Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling.Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.An intermediate state of the gamma-aminobutyric acid transporter GAT1 revealed by simultaneous voltage clamp and fluorescence.Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor.An inverse relationship links temperature and substrate apparent affinity in the ion-coupled cotransporters rGAT1 and KAAT1.Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia.Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango.Teleost fish models in membrane transport research: the PEPT1(SLC15A1) H+-oligopeptide transporter as a case study.Structure, function, and plasticity of GABA transporters.Conformational changes represent the rate-limiting step in the transport cycle of maize sucrose transporter1.Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1.Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodes.GAT1 (GABA:Na+:Cl-) cotransport function. Kinetic studies in giant Xenopus oocyte membrane patches.Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each otherTransmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket.No easy way out (or in)GAT1 (GABA:Na+:Cl-) cotransport function. Steady state studies in giant Xenopus oocyte membrane patches.Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.An acidic amino acid transmembrane helix 10 residue conserved in the neurotransmitter:sodium:symporters is essential for the formation of the extracellular gate of the γ-aminobutyric acid (GABA) transporter GAT-1.Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1.
P2860
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P2860
GAT1 (GABA:Na+:Cl-) cotransport function. Database reconstruction with an alternating access model.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
GAT1 (GABA:Na+:Cl-) cotranspor ...... h an alternating access model.
@en
type
label
GAT1 (GABA:Na+:Cl-) cotranspor ...... h an alternating access model.
@en
prefLabel
GAT1 (GABA:Na+:Cl-) cotranspor ...... h an alternating access model.
@en
P2860
P356
P1476
GAT1 (GABA:Na+:Cl-) cotranspor ...... h an alternating access model.
@en
P2093
P2860
P304
P356
10.1085/JGP.114.3.459
P577
1999-09-01T00:00:00Z