LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
about
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradationThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionA microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.Somatic LKB1 mutations promote cervical cancer progression.PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cellsLKB1 preserves genome integrity by stimulating BRCA1 expression.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersReduction behavior induced by HL010183, a metformin derivative against the growth of cutaneous squamous cell carcinoma.Integrating physiological regulation with stem cell and tissue homeostasisMetformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway.Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinomaHyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.LKB1; linking cell structure and tumor suppression.Tumor suppressors and cell metabolism: a recipe for cancer growth.Targeting the LKB1 tumor suppressor.LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.Molecular mechanisms of tumor suppression by LKB1.LKB1 loss of function studied in vivo.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.The LKB1 complex-AMPK pathway: the tree that hides the forestThe tumor suppressor kinase LKB1: lessons from mouse models.Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor.Role of AMP-activated protein kinase in cancer therapy.Epidermal polarity genes in health and diseaseComparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundariesA unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.LKB1/PEA3/ΔNp63 pathway regulates PTGS-2 (COX-2) transcription in lung cancer cells upon cigarette smoke exposureInactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
P2860
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P2860
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@en
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@nl
type
label
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@en
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@nl
prefLabel
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@en
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@nl
P2093
P2860
P1433
P1476
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
@en
P2093
Aram F Hezel
Ergun Sahin
Justin H Berger
Marcus W Bosenberg
Nabeel Bardeesy
Sushma Gurumurthy
P2860
P356
10.1158/0008-5472.CAN-07-3225
P407
P577
2008-01-01T00:00:00Z