LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. - Wikidata - wikimedia - TriplyDB

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

http://www.wikidata.org/entity/Q42547962

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A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation The LKB1-AMPK pathway: metabolism and growth control in tumour suppression A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.Somatic LKB1 mutations promote cervical cancer progression.PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells LKB1 preserves genome integrity by stimulating BRCA1 expression.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers Reduction behavior induced by HL010183, a metformin derivative against the growth of cutaneous squamous cell carcinoma.Integrating physiological regulation with stem cell and tissue homeostasis Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway.Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.LKB1; linking cell structure and tumor suppression.Tumor suppressors and cell metabolism: a recipe for cancer growth.Targeting the LKB1 tumor suppressor.LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.Molecular mechanisms of tumor suppression by LKB1.LKB1 loss of function studied in vivo.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.The LKB1 complex-AMPK pathway: the tree that hides the forest The tumor suppressor kinase LKB1: lessons from mouse models.Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor.Role of AMP-activated protein kinase in cancer therapy.Epidermal polarity genes in health and disease Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.LKB1/PEA3/ΔNp63 pathway regulates PTGS-2 (COX-2) transcription in lung cancer cells upon cigarette smoke exposure Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.

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P2860

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

http://www.wikidata.org/entity/Q42547962

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

@en

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

@nl

type

label

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

@en

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

@nl

prefLabel

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

@en

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

@nl

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0008-5472.CAN-07-3225

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Cancer Research

P1476

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

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P2093

Aram F Hezel

http://www.w3.org/2001/XMLSchema#string

Ergun Sahin

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Justin H Berger

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Marcus W Bosenberg

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Nabeel Bardeesy

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Sushma Gurumurthy

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

The LKB1 tumor suppressor negatively regulates mTOR signaling

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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55-63

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10.1158/0008-5472.CAN-07-3225

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1

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Nabeel Bardeesy

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5678099

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18172296

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3739055

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