Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
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MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersMolecular regulation of NKCC2 in the thick ascending limbIdentification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lensesA SPAK isoform switch modulates renal salt transport and blood pressureRegulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Identification of two novel mutations in SLC12A3 gene in two Chinese pedigrees with Gitelman syndrome and review of literature.Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expressionIncreasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis.Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb.Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndromeSPAK-mediated NCC regulation in response to low-K+ dietSPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Critical role of the SPAK protein kinase CCT domain in controlling blood pressureShort-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron.A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporterCharacterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron.SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activityCalcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ CotransporterA minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivoOsmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathwaySPAK differentially mediates vasopressin effects on sodium cotransporters.Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex propertiesThe CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyThe Drosophila NKCC Ncc69 is required for normal renal tubule functionPhosphorylation regulates NCC stability and transporter activity in vivoNovel diuretic targetsPhysiology and pathophysiology of SLC12A1/2 transporters.Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibitionDirect control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosteroneAnnexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter.WNK3 is a putative chloride-sensing kinase.Na+-K+-2Cl- cotransporter type 2 trafficking and activity: the role of interacting proteins.Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).
P2860
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P2860
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@en
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@nl
type
label
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@en
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@nl
prefLabel
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@en
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@nl
P2093
P2860
P356
P1476
Regulation of the NKCC2 ion co ...... ent and -independent pathways.
@en
P2093
Ciaran Richardson
David G Campbell
Kei Sakamoto
Maria Deak
Paola de los Heros
P2860
P304
P356
10.1242/JCS.077230
P407
P577
2011-03-01T00:00:00Z