Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. - Wikidata - wikimedia - TriplyDB

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

http://www.wikidata.org/entity/Q42757015

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MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters Molecular regulation of NKCC2 in the thick ascending limb Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses A SPAK isoform switch modulates renal salt transport and blood pressure Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2 Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Identification of two novel mutations in SLC12A3 gene in two Chinese pedigrees with Gitelman syndrome and review of literature.Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis.Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb.Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome SPAK-mediated NCC regulation in response to low-K+ diet SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Critical role of the SPAK protein kinase CCT domain in controlling blood pressure Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron.A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron.SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ Cotransporter A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway SPAK differentially mediates vasopressin effects on sodium cotransporters.Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy The Drosophila NKCC Ncc69 is required for normal renal tubule function Phosphorylation regulates NCC stability and transporter activity in vivo Novel diuretic targets Physiology and pathophysiology of SLC12A1/2 transporters.Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition Direct control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosterone Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter.WNK3 is a putative chloride-sensing kinase.Na+-K+-2Cl- cotransporter type 2 trafficking and activity: the role of interacting proteins.Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).

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Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

http://www.wikidata.org/entity/Q42757015

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@en

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@nl

type

label

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@en

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@nl

prefLabel

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@en

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@nl

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P1433

Journal of Cell Science

P1476

Regulation of the NKCC2 ion co ...... ent and -independent pathways.

@en

P2093

Ciaran Richardson

http://www.w3.org/2001/XMLSchema#string

David G Campbell

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Kei Sakamoto

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Maria Deak

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Paola de los Heros

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P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

The selectivity of protein kinase inhibitors: a further update

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells

PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)

Human hypertension caused by mutations in WNK kinases

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789-800

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scholarly article

P356

10.1242/JCS.077230

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P433

Pt 5

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P478

124

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Alan R. Prescott

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2011-03-01T00:00:00Z

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P698

21321328

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P932

3114804

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