Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation.
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GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinaseDiscovery of p1736, a novel antidiabetic compound that improves peripheral insulin sensitivity in mice modelsAdipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalizationPhosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110.A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes.ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes.NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway.Intracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues (review).Activation of the glucose transporter GLUT4 by insulin.Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubulesThe hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway.PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes.A long search for Glut4 activation.Separation of insulin signaling into distinct GLUT4 translocation and activation steps.Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes.Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrationsInsulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.Acute effectors of GLUT1 glucose transporter subcellular targeting in CIT3 mouse mammary epithelial cells.Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation.Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport.Maternal protein restriction during early lactation induces GLUT4 translocation and mTOR/Akt activation in adipocytes of adult rats.MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3.Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin.Characterization of the insulin-regulated endocytic recycling mechanism in 3T3-L1 adipocytes using a novel reporter molecule.The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1.Expression of constitutively active Akt/protein kinase B signals GLUT4 translocation in the absence of an intact actin cytoskeleton.Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.
P2860
Q28362404-FB3FE9A4-C9AE-4DD5-B85E-CDD4E1C75513Q28534604-03E2BE34-9F77-462B-9D8A-9B60CFDECEE1Q28587742-FB8139B1-6B80-4019-96FE-5CFF91264322Q30167836-2D57061C-2415-4AE5-989E-7C9924C6F972Q30865851-88786C45-F208-49C8-8C0E-10729A771561Q33195747-EA8F1EB8-0E0F-45DB-944C-C819CAC8762FQ33781146-A1670FE3-D032-400C-AD1C-AD599399246EQ33954068-48065F7A-872C-477F-996E-C20764C64D3EQ33969136-021A9182-D1C5-4CAD-94C6-8BB0EFDA77C9Q34128449-7D4FE14D-A81E-49B3-821B-DACF87985C7DQ34420437-8B2E03AC-A568-4805-A82E-98F29EB0EF51Q35003156-652AC8D4-339B-4AAC-9DC5-C0055905F659Q35016947-C518FFBA-C8CD-4E6E-A662-898F657BA5DBQ35049130-37E832D8-7316-46E7-A245-9CAAD575A9DAQ35055046-85D59273-B743-4C76-8116-EE834512C9ADQ35064714-C813EBF8-9E53-466F-919D-192BDCC2BE13Q37349880-D12F0F29-232D-4662-BE77-BCFD07DCBB6AQ37537923-DD232C87-0C08-402E-ABA1-0C4564C2F781Q37543490-323DFBB3-F730-43BF-8371-207E3275491CQ38334079-433C470C-59EA-4BFE-85F5-C5238A7D215CQ38409013-AED54F37-E0FB-4085-A8F0-B2CD65E46FCCQ39460118-93CDCAA8-2CF9-4892-8E9D-F23CCE340A18Q39831978-C2113882-11AC-4C65-A26F-A4A96DF0D492Q40043747-D0A5F155-35E0-4ECE-AF10-D38E8173294FQ40654612-413D6960-36B7-469C-ADB3-437A3ABBAE93Q40775117-0553F2EF-61F5-4794-8A94-5EA2611FD085Q42437514-2A7F5D84-8A89-4393-8992-AAE979AD6A8FQ42502044-ACD8BF92-BD05-465C-8A2B-2A20B1948FB9Q42504933-961DDA33-9513-41F4-957B-C438380D6038Q42801373-4810C94C-5960-41F7-95B7-56D4C325AF96Q42805489-327D5ABB-9C0E-492A-A8C6-3F80B242BE5BQ42814621-12284E5D-4E05-4E74-95FB-5CD4591ADACCQ42817631-F3366889-09A5-4DEF-AE6F-CAFD9561048AQ42828593-4FD96FE8-2E0E-43C8-B741-D5C412EB8F87Q44517542-0C66D8E9-1C20-4853-8A1F-CB77C18C2EC8Q44564199-5E17D25D-D325-46AE-BF12-44572F1CD4BB
P2860
Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Identification of wortmannin-s ...... ptake and glut4 translocation.
@en
Identification of wortmannin-s ...... ptake and glut4 translocation.
@nl
type
label
Identification of wortmannin-s ...... ptake and glut4 translocation.
@en
Identification of wortmannin-s ...... ptake and glut4 translocation.
@nl
prefLabel
Identification of wortmannin-s ...... ptake and glut4 translocation.
@en
Identification of wortmannin-s ...... ptake and glut4 translocation.
@nl
P2093
P2860
P356
P1476
Identification of wortmannin-s ...... uptake and glut4 translocation
@en
P2093
D C Fingar
E L Whiteman
S A Summers
S F Hausdorff
P2860
P304
24677-24684
P356
10.1074/JBC.274.35.24677
P407
P577
1999-08-01T00:00:00Z