Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
about
Landmarks in insulin researchAdapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interactionPurified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinityHow insulin engages its primary binding site on the insulin receptorThe preparation of monoclonal antibodies to human bone and liver alkaline phosphatase and their use in immunoaffinity purification and in studying these enzymes when present in serumMolecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analoguesEngineering of insulin receptor isoform-selective insulin analoguesInsulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.A monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptorsInsulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo.Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptorMonoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor moleculesSynchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer.Agonism and antagonism at the insulin receptor.Structure of the insulin receptor ectodomain reveals a folded-over conformation.Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin.Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinityMechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes.IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718.Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cellsTransdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.Antibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin action.Mutagenic structure/function analysis of the cytoplasmic cysteines of the insulin receptor.Cysteine-524 is not the only residue involved in the formation of disulphide-bonded dimers of the insulin receptorComparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor.Function of insulin in snail brain in associative learning.High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival.N-linked glycans of the human insulin receptor and their distribution over the crystal structure.Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.Mutational analysis of the N-linked glycosylation sites of the human insulin receptor
P2860
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P2860
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@en
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@nl
type
label
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@en
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@nl
prefLabel
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@en
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@nl
P2093
P2860
P356
P1433
P1476
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.
@en
P2093
Bellatin J
P2860
P304
P356
10.1042/BJ2350199
P407
P577
1986-04-01T00:00:00Z