Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
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Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation siteEnhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigenInhibitory activity of fenoterol on Dermatophagoides-, Parietaria-, tetanus-toxoid-, and Candida albicans-stimulated blood mononuclear cells: differences in beta2-adrenoreceptor stimulation but not in cell apoptosis.T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.Thymic epithelial cells induce in vitro differentiation of PRO-T lymphocyte clones into TCR alpha,beta/T3+ and TCR gamma,delta/T3+ cells.Bacterial and viral superantigens: roles in autoimmunity?Superantigens: mechanisms by which they may induce, exacerbate and control autoimmune diseases.Mink cell focus-forming murine leukemia virus infection induces apoptosis of thymic lymphocytes.A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptorT-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.Hormonal regulation of physiological cell turnover and apoptosis.Clonal deletion of specific thymocytes by an immunoglobulin idiotype.IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotypeIntrathymic maturation of murine T lymphocytes from CD8+ precursorsThe impact of circulating dendritic cells on the development and differentiation of thymocytes.Development of the CD4 and CD8 lineage of T cells: instruction versus selection.Defect in negative selection in lpr donor-derived T cells differentiating in non-lpr host thymus.CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen typeAcquired Mls-1a-like clonal deletion in Mls-1b miceIn vivo and in vitro clonal deletion of double-positive thymocytes.Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.CD8 is required during positive selection of CD4-/CD8+ T cellsT cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergyDeletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selectionRole of CD4 in thymocyte selection and maturation.Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.Reactivity of V beta 17a+ CD8+ T cell hybrids. Analysis using a new CD8+ T cell fusion partnerBacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model.Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate.Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28Differential effects of zeta and eta transgenes on early alpha/beta T cell development.Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor betaSusceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen.
P2860
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P2860
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh-hant
name
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@en
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@nl
type
label
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@en
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@nl
prefLabel
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@en
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@nl
P2093
P356
P1433
P1476
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
@en
P2093
Fowlkes BJ
Pardoll DM
Schwartz RH
P2888
P304
P356
10.1038/334620A0
P407
P577
1988-08-01T00:00:00Z
P6179
1048976895