Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
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Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signalingNovel GPCR paradigms at the μ-opioid receptorMuscarinic acetylcholine receptor modulation of mu (mu) opioid receptors in adult rat sphenopalatine ganglion neurons.Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent ratsLigand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.Clinical efficacy of sustained-release buprenorphine with meloxicam for postoperative analgesia in beagle dogs undergoing ovariohysterectomy.μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment.Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neuronsMorphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activationAgonist-selective mechanisms of GPCR desensitizationOpioid receptor desensitization: mechanisms and its link to toleranceCellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)In vivo opioid receptor heteromerization: where do we stand?β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.Influence of agonist intrinsic activity on the desensitisation of beta2-adrenoceptor-mediated responses in mast cells.Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine.Differential activation and trafficking of micro-opioid receptors in brain slices.A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro.Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to humanChronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.Intrathecal ziconotide for refractory pain.Opioid receptor internalization contributes to dermorphin-mediated antinociceptionMu-opioid receptor desensitization: is morphine different?Effects of chronic opioid exposure on guinea pig mu opioid receptor in Chinese hamster ovary cells: comparison with human and rat receptorMechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.Agonist Binding and Desensitization of the μ-Opioid Receptor Is Modulated by Phosphorylation of the C-Terminal Tail Domain.Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons.Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors.Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents.Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction.
P2860
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P2860
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@en
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@nl
type
label
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@en
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@nl
prefLabel
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@en
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@nl
P2860
P50
P356
P1476
Opioid agonists have different ...... ytosis of mu-opioid receptors.
@en
P2093
MacDonald J Christie
P2860
P304
18776-18784
P356
10.1074/JBC.M300525200
P407
P577
2003-03-17T00:00:00Z