New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathwaysCryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growthNeuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhageResveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialLong-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsAn educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.Fluorinated porphyrinoids as efficient platforms for new photonic materials, sensors, and therapeutics.Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondriaA new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumorsReactive nitrogen species reactivities with nitrones: theoretical and experimental studies.Gelam honey scavenges peroxynitrite during the immune responseCytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itselfPharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceImpact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorSimple biological systems for assessing the activity of superoxide dismutase mimics.Roles of reactive oxygen and nitrogen species in painTexaphyrins: tumor localizing redox active expanded porphyrinsManganese superoxide dismutase, MnSOD and its mimicsDesign, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Therapeutic potential of peroxynitrite decomposition catalysts: a patent review.Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages.Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activityA comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.
P2860
Q28385000-63EB042F-6CF2-4D49-9CB2-B2A0C087F234Q28389277-5E1F62E0-126A-4A59-B90E-5E77D42BD35FQ33719087-F1D13E5B-E911-4B61-91E1-6ED7293DCED8Q33926426-B9746E76-D113-4AA6-BAA3-BAA54E626CD0Q34108098-30741A4A-446C-4DCB-925D-DDC1C6F8AAC6Q34110107-AFD030ED-9EE8-47FD-B9FB-1F2119AD0212Q34284412-366D8A11-2C72-4442-B754-6033637560A6Q34455737-573CB3E0-13A1-4615-B0F1-DD6A4F540F62Q34500616-4EC92E0E-28D7-4D34-B534-B5F4435789C3Q35177269-97173EF5-F7E1-4B4D-9425-6F619511CEB6Q35228718-FBADC269-C76C-4FCE-A209-E61E4F264AFAQ35349280-54002E47-3D15-43F7-8A90-46706213F246Q35496324-798CFD89-416D-48E1-9E6D-22FD8C207AF8Q35569305-9BE6A89D-B633-4540-AEF1-72F34CF6A742Q35674922-335D4170-619E-44D7-BB3F-B2F65C7C8392Q35826474-D61FE986-2DA3-4FE3-B9CC-60FAC9296071Q35910892-EBD3699D-ED42-4164-B81C-67254AA6C446Q35965059-3E59E321-8B48-40A3-806B-FC9B41B2EC57Q35976820-F05DF050-1713-42DB-BF1B-F9B827AFE625Q36190524-9A15E0B0-C52B-49A0-A98A-F349AEA43FA8Q36321908-EB5DE471-7002-4410-AE5A-B31FB5692809Q36406467-385A3475-ECFE-4C20-AAF3-71455A40376CQ36839447-61A2E3D5-55A7-4C55-A990-3890FFF99144Q36961432-4CDD8F48-B15E-416C-93A0-4CF39D24C850Q36973998-6ECD08F9-C738-4F27-98D1-8628526344F5Q37038133-D46A3ADF-C16E-4183-8E02-D4183A964C53Q37063743-EEA0E2A3-9A84-4C2B-9A29-4A13583F2838Q37222820-4835B578-6AB1-4131-BC2A-0C2E42550DBCQ37342759-5C63E9CC-6233-4850-B279-6A12AD4FC71AQ37358536-7A309597-5856-47C8-8305-875305923B29Q37734019-2373D35C-E760-4D64-9D9A-CAF09EBB2EB0Q37833285-F696F54B-5077-46DE-BAE6-9CA70482C2CDQ37847606-81E1344C-21F1-4552-9EE7-9AD9378B7E21Q37971277-707729EB-E512-4A12-963D-6D076955CD74Q38053032-FBC1761F-6FDB-424C-8115-8ABF009A28C5Q38313367-7F0D5A8B-39B6-4B16-BB8C-C2294D4D7D51Q39381731-98BC0A09-6DC8-435D-8F6D-A86D800609E8Q40655619-ED60B9B5-AF11-4045-B8C1-DA6BC25AA4B6Q41327195-1FBBBE15-F81B-41E4-89D5-34CA5EEDC8E7Q41812704-F00ED70B-D921-4625-A033-D568A0DBC906
P2860
New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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2004年學術文章
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name
New class of potent catalysts of O2.-dismutation. Mn
@nl
New class of potent catalysts ...... hoxyethylimidazolylporphyrins.
@en
type
label
New class of potent catalysts of O2.-dismutation. Mn
@nl
New class of potent catalysts ...... hoxyethylimidazolylporphyrins.
@en
prefLabel
New class of potent catalysts of O2.-dismutation. Mn
@nl
New class of potent catalysts ...... hoxyethylimidazolylporphyrins.
@en
P2093
P2860
P356
P1433
P1476
New class of potent catalysts ...... hoxyethylimidazolylporphyrins.
@en
P2093
Ayako Okado-Matsumoto
Ines Batinić-Haberle
Irwin Fridovich
Ivan Spasojević
Pedatsur Neta
Peter Hambright
Robert D Stevens
P2860
P304
P356
10.1039/B400818A
P407
P577
2004-05-05T00:00:00Z