Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits.
about
Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthasesCracking the polyketide codeInhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase † , ‡Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketidesStructural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide KetoreductaseEvolution of polyketide synthases in bacteriaAn antibiotic factory caught in actionIdentification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzymeThe Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesisCombinatorial biosynthesis of polyketides--a perspective.Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapesDiscovery and development of antineoplastic agents from natural sources.Microbial polyketide synthases: more and more prolific.Structural enzymology of polyketide synthases.Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydraseCyclization of aromatic polyketides from bacteria and fungiClassification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.Biosynthesis of polyketides in heterologous hostsEngineered biosynthesis of aklanonic acid analoguesEngineered polyketide biosynthesis and biocatalysis in Escherichia coli.The enzymology of combinatorial biosynthesis.Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms.Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesisEngineering precision RNA molecular switches.Genetics of Streptomyces rimosus, the oxytetracycline producer.Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.Evolutionally guided enzyme design.Biosynthesis of aromatic polyketides in bacteria.Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthaseStrategies for protein synthetic biology.The structural role of the carrier protein--active controller or passive carrier.Engineering of peptide synthetases. Key role of the thioesterase-like domain for efficient production of recombinant peptides.Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteinsEngineering anthracycline biosynthesis toward angucyclines.Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57.Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells.Kinetic analysis of the actinorhodin aromatic polyketide synthase.
P2860
Q24796064-E5C7D933-C249-41DA-9F2F-BDC6B6F16259Q24796089-08BD122A-7774-4AE9-8B9C-065C33EFE0E5Q27649562-1F6998FE-553F-4429-A577-DC037516D4BCQ27650227-33347752-9EE3-4FF1-92A6-539A4714C6FEQ27667477-7B21C51C-9A8D-4AE0-AEBB-AF0CCF2DA6E9Q28267392-F38BA6B8-44D8-4580-BDD6-72832FA0C069Q28275079-FB3DA39D-9905-471F-BB0C-E3E09A819683Q28379008-71714596-D010-4EDC-BFF9-BABAD6B482B2Q28379486-CA592456-0BAD-4A6B-AE0A-A394B0F56086Q30413205-4BC22CAF-48AE-4FFC-B3AF-0F40D4622625Q30650504-BEBAAFA1-DE5D-4379-B6EB-10A0CA118E34Q30657940-24864927-0D58-4444-87E7-63FB33A8DB17Q33539960-659309BC-72A8-4066-B934-65EB69CED20AQ33546208-518B1EB7-D7DC-4F00-B7F8-760AD1348FD2Q33862817-A615C73B-5208-46F6-9B8C-29F362147076Q33906512-1321A323-2366-4EC1-A064-9C48FF6D8D5BQ33910335-2B5D5F3B-8BF8-410C-A909-48AC7C8381EAQ34003788-28D892E8-909C-45FF-B968-31A77A837960Q34010324-9EEB9075-AE93-4923-ACC3-6DB9ED281633Q34293749-A2AA403C-CA6F-495B-9F83-0187D6D1F137Q34311936-F7DE07D5-95AC-46C5-BED1-D034ED7B0C5DQ35188415-91F46842-E7F9-49CC-B595-B20B4856000CQ35619018-46697ACF-A600-4B78-A1D3-07B33B2C82D8Q35633135-153B2377-74B6-4699-8281-491BF7DA9215Q36018354-A408440F-A83E-45E4-A4F6-86BC8449C668Q36444768-9046FA79-C5C7-42C8-B824-7553C9BE1639Q36588777-D5DCEB36-BB52-4F0B-A392-87AF58A2CD98Q37081542-23FEF16E-DDAD-4DF0-8A9B-1FB26227E1E7Q37217470-EFD5378C-917C-4EBD-9E9D-363CEDC0F549Q37416691-49E05913-2329-40F1-AAA4-FC2B2DF82712Q37533052-CC802AEE-0B90-4A61-AE6E-E1A12B48854AQ37729531-BFEA82C3-6794-4513-B370-363FE150A156Q38038812-9630763A-216F-47A7-8DDE-4F3DDAB3B7DBQ38342820-CA42355D-0A31-43E6-864D-1D944B97B651Q39427118-ED47AB5B-3CD3-48A4-B4DC-E53584435DECQ39743465-6534E784-D69A-40EC-B769-260B5C1D3E75Q39847489-776B3220-70E0-47AF-9DF8-B41FA4AE3208Q39847577-3D28C5F1-0F0E-4008-BD93-B6606F28E8A7Q41042013-CBA485B8-FA04-46D0-BA1B-D073F7753CF7Q41686123-7F78CDC4-19A2-4877-AA5F-54FAB8F6404E
P2860
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@en
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@nl
type
label
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@en
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@nl
prefLabel
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@en
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@nl
P2093
P356
P1433
P1476
Rational design of aromatic po ...... ssembly of enzymatic subunits.
@en
P2093
Ebert-Khosla S
Hopwood DA
McDaniel R
P2888
P304
P356
10.1038/375549A0
P407
P577
1995-06-01T00:00:00Z
P6179
1017785037