Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
about
Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growthIdentification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionDLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic developmentThe hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory functionThe eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathwayCDC42 and FGD1 cause distinct signaling and transforming activities.Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformationVav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrinsRegulatory and signaling properties of the Vav familyRational design of small molecule inhibitors targeting RhoA subfamily Rho GTPasesInactivation of Icmt inhibits transformation by oncogenic K-Ras and B-RafEndogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathwayp19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathwaysGene trapping identifies transiently induced survival genes during programmed cell deathScambio, a novel guanine nucleotide exchange factor for RhoStructure of the BH domain from graf and its implications for Rho GTPase recognitionSmall-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growthCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein betaThe trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domainLeukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoAThe serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosisActivated PAK4 regulates cell adhesion and anchorage-independent growthLoss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathwaysIdentification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMPIdentification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoformIsoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation siteGene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte developmentVav2 is an activator of Cdc42, Rac1, and RhoARational design and characterization of a Rac GTPase-specific small molecule inhibitorSignaling between focal adhesion kinase and trio.BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling.Distinct expression patterns and transforming properties of multiple isoforms of Ost, an exchange factor for RhoA and Cdc42.Epithelial cell cytoskeleton and intracellular trafficking V. Confluence of membrane trafficking and motility in epithelial cell models.G2A is an oncogenic G protein-coupled receptor.The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.RhoA of the Rho family small GTPases is essential for B lymphocyte development.Rig is a novel Ras-related protein and potential neural tumor suppressorA novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
P2860
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P2860
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@en
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@nl
type
label
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@en
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@nl
prefLabel
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@en
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@nl
P2093
P356
P1433
P1476
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202181
P407
P433
11 Reviews
P577
1998-09-01T00:00:00Z