The Amino-terminal Domain of Apolipoprotein B Does Not Undergo Retrograde Translocation from the Endoplasmic Reticulum to the Cytosol
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Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cellsApolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosisEpigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDLMicrosomal triglyceride transfer protein and its role in apoB-lipoprotein assemblyApolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins.Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease.Role of the gut in lipid homeostasisApolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly.The pathophysiology of intestinal lipoprotein production.Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER.Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasome.Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.Translocation efficiency of apolipoprotein B is determined by the presence of beta-sheet domains, not pause transfer sequences.
P2860
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P2860
The Amino-terminal Domain of Apolipoprotein B Does Not Undergo Retrograde Translocation from the Endoplasmic Reticulum to the Cytosol
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Oktober 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2000
@uk
name
The Amino-terminal Domain of A ...... asmic Reticulum to the Cytosol
@en
The Amino-terminal Domain of A ...... asmic Reticulum to the Cytosol
@nl
type
label
The Amino-terminal Domain of A ...... asmic Reticulum to the Cytosol
@en
The Amino-terminal Domain of A ...... asmic Reticulum to the Cytosol
@nl
prefLabel
The Amino-terminal Domain of A ...... asmic Reticulum to the Cytosol
@en
The Amino-terminal Domain of A ...... asmic Reticulum to the Cytosol
@nl
P2093
P2860
P356
P1476
The amino-terminal domain of a ...... ill in its original translocon
@en
P2093
P2860
P304
32003-32010
P356
10.1074/JBC.M004646200
P407
P577
2000-10-01T00:00:00Z