A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter
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Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and CognitionAstrocytes are central in the pathomechanisms of vanishing white matterCrystal structure of eukaryotic translation initiation factor 2BAltered Translational Control of FMRP on Myelin Proteins in Neuropsychiatric DisordersPoor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter diseaseA yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM diseaseDevelopmental splicing deregulation in leukodystrophies related to EIF2B mutationsA point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.CSF N-glycan profiles to investigate biomarkers in brain developmental disorders: application to leukodystrophies related to eIF2B mutationsImpaired eIF2B activity in ligodendrocytes contributes to VWMD pathogenesis.Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter diseaseProteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease.A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination.GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway.Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.Molecular patterns of neurodevelopmental preconditioning: a study of the effects of antenatal steroid therapy in a protein-restriction mouse model.New insights into translational regulation in the endoplasmic reticulum unfolded protein response.ASTROCYTES: EMERGING STARS IN LEUKODYSTROPHY PATHOGENESIS.Translational control by eIF2α in neurons: Beyond the stress response.Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating gliaInherited and acquired disorders of myelin: The underlying myelin pathology.Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.Endoplasmic Reticulum Protein Quality Control Failure in Myelin Disorders.Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration.Mitochondrial malfunction in vanishing white matter disease: a disease of the cytosolic translation machinery.Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle.Axonal abnormalities in vanishing white matter.The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy
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P2860
A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter
description
article
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im August 2010 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
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наукова стаття, опублікована в серпні 2010
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name
A mouse model for eukaryotic t ...... elopment of brain white matter
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A mouse model for eukaryotic t ...... elopment of brain white matter
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type
label
A mouse model for eukaryotic t ...... elopment of brain white matter
@en
A mouse model for eukaryotic t ...... elopment of brain white matter
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prefLabel
A mouse model for eukaryotic t ...... elopment of brain white matter
@en
A mouse model for eukaryotic t ...... elopment of brain white matter
@nl
P2093
P356
P1433
P1476
A mouse model for eukaryotic t ...... elopment of brain white matter
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P2093
Dalia Pinchasi
Gali Raini
Liraz Marom
Michal Geva
Nina Mindroul
Yaniv Assaf
Yuval Cabilly
P304
P356
10.1093/BRAIN/AWQ180
P407
P577
2010-08-01T00:00:00Z