Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. - sprookjes - yvandenbroek - TriplyDB

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

http://www.wikidata.org/entity/Q45159091

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Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif Ubiquitylation-dependent downregulation of Nck regulates its functional activity Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains Cooperative interactions at the SLP-76 complex are critical for actin polymerization Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.Dynamic Regulation of TCR-Microclusters and the Microsynapse for T Cell Activation Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse Human Immunodeficiencies Related to Defective APC/T Cell Interaction WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm Super-resolution characterization of TCR-dependent signaling clusters Controversy and consensus regarding myosin II function at the immunological synapse Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling Ligand mobility modulates immunological synapse formation and T cell activation WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site Altered actin centripetal retrograde flow in physically restricted immunological synapses Natural killer cell signal integration balances synapse symmetry and migration Hierarchical nanostructure and synergy of multimolecular signalling complexes.Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation Phosphorylation site dynamics of early T-cell receptor signaling Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.Mechanism and function of Vav1 localisation in TCR signalling.Stoichiometry of Nck-dependent actin polymerization in living cells Studies of novel interactions between Nck and VAV SH3 domains.Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.In vivo significance of ITK-SLP-76 interaction in cytokine production.The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes Nck adapter proteins: functional versatility in T cells Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.Persistence of cooperatively stabilized signaling clusters drives T-cell activation Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells.c-Cbl-mediated regulation of LAT-nucleated signaling complexes T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.

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Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

http://www.wikidata.org/entity/Q45159091

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2004 nî lūn-bûn

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Dynamic molecular interactions ...... tor to the actin cytoskeleton.

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Dynamic molecular interactions ...... tor to the actin cytoskeleton.

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Dynamic molecular interactions ...... tor to the actin cytoskeleton.

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Dynamic molecular interactions ...... tor to the actin cytoskeleton.

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Dynamic molecular interactions ...... tor to the actin cytoskeleton.

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Dynamic molecular interactions ...... tor to the actin cytoskeleton.

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Nature Immunology

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Dynamic molecular interactions ...... ptor to the actin cytoskeleton

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Alex Braiman

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Lawrence E Samelson

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Mira Barda-Saad

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Rachel Titerence

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Valarie A Barr

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P2860

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

The immunological synapse: a molecular machine controlling T cell activation

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80-89

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10.1038/NI1143

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1

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6

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Stephen C Bunnell

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2004-11-21T00:00:00Z

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8169440

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