about
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseStructure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Sld2 binds to origin single-stranded DNA and stimulates DNA annealing.Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentSensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase εPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombeETAA1 acts at stalled replication forks to maintain genome integrityAssembly of Slx4 signaling complexes behind DNA replication forksThe Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural OrganizationA truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae.Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenanceReconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanismCell biology of mitotic recombination.Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability.Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo.RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machineryATR signalling: more than meeting at the fork.Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint responseCooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA.Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1.A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae.Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Dpb11 activates the Mec1-Ddc2 complex
@en
type
label
Dpb11 activates the Mec1-Ddc2 complex
@en
prefLabel
Dpb11 activates the Mec1-Ddc2 complex
@en
P2093
P2860
P356
P1476
Dpb11 activates the Mec1-Ddc2 complex
@en
P2093
Daniel A Mordes
David Cortez
Edward A Nam
P2860
P304
18730-18734
P356
10.1073/PNAS.0806621105
P407
P577
2008-11-21T00:00:00Z