Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.
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RNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionConservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmissionHIV-1 reverse transcriptionTime-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living CellsStructural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed InhibitorsCrystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease HStructures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavageConservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patientsRibonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Alternate polypurine tracts (PPTs) affect the rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction.Specific recognition and cleavage of the plus-strand primer by reverse transcriptase.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.The "Connection" Between HIV Drug Resistance and RNase HThe N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in repMutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance.Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection.Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine.Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivoMutations in the 5' end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer.Mutations in the human immunodeficiency virus type 1 polypurine tract (PPT) reduce the rate of PPT cleavage and plus-strand DNA synthesis.Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase.Tighter binding of HIV reverse transcriptase to RNA-DNA versus DNA-DNA results mostly from interactions in the polymerase domain and requires just a small stretch of RNA-DNA.Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases.Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients.Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.Dynamic binding orientations direct activity of HIV reverse transcriptaseEffects of raltegravir on 2-long terminal repeat circle junctions in HIV type 1 viremic and aviremic patientsSubtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavageMutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer.
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P2860
Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@ast
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@en
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@nl
type
label
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@ast
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@en
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@nl
prefLabel
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@ast
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@en
Mutations in the RNase H domai ...... y of RNase H cleavage in vivo.
@nl
P2860
P50
P356
P1476
Mutations in the RNase H domai ...... ty of RNase H cleavage in vivo
@en
P2093
Edward Arnold
John G Julias
P2860
P304
P356
10.1073/PNAS.142123199
P407
P577
2002-07-01T00:00:00Z